Thursday, September 15, 2011

Use Of Prednisone And Lovenox For IVF Cycle With Donor Eggs: How Long?


Dr. Ramirez:

I am a 44-yr old with a history of numerous IVF attempts. Miraculously, cycle 1 (2007) with my own egg (yes, only one egg was retrieved) resulted in a healthy baby. 1 additional IVF attempt (2009) with my own egg - unsuccessful. Subsequently, 4 IVF attempts with two different donors (some fresh, some frozen cycles) were also unsuccessful. With each attempt, the blastocysts were high-grade, and other recipients of same donor's eggs resulted in pregnancies.

For my current cycle, which begins this week, we will be using a cryopreserved embryo, and physician is adding two medications: Prednisolone 25 mg daily, starting 10 days before transfer, and Lovenox 40mg daily, starting 2 days prior to transfer. If successful, plan is to continue both meds (along with Estrogen and Progesterone injections) for the first trimester. This seems like an extremely large dose of prednisolone and lengthy duration. I am concerned about the potential side effects on me, as well as the developing fetus, assuming a positive outcome. Do you have any experience and/or information regarding the prednisolone and Lovenox? Thank you, C. from the U.S.


Hello C. from the U.S.,

In my patients that fail 2 IVF cycles, I automatically add prednisone, Heparin (lovenox can be used as well). All my IVF patients get the prednisone (I use medrol), low dose aspirin, progesterone and estrogen, so in reality the only thing that is new is the heparin/lovenox. Because of the potential effects on the developing fetus, I do not use the prednisone longer that the first pregnancy test. The heparin, aspirin, progesterone and estrogen are continued until the patient reaches 10 weeks gestational age. In patients that have a history of recurrent miscarriages, I will sometimes continue the medications until 12 weeks gestational age.

I start the heparin (lovenox) with the start of the IVF cycle, just like I do with the prednisone and aspirin.

Incidentally, your experience with a pregnancy in the first IVF cycle with only one embryo transferred, at the age of 40, is the reason why I DON'T ever cancel a cycle if there is only 1-3 follicles. My belief is that this one egg may lead to the one perfect embryo left and I would hate to lose the opportunity to get a pregnancy from it. It may be a lower chance, but it is still the best chance that you've got. So I am glad to hear that your docs continued the cycle and did not cancel it like so many do!

Good luck with your upcoming donor cycle.

Dr. Edward J. Ramirez, M.D., FACOG
Executive Medical Director
The Fertility and Gynecology Center
Monterey Bay IVF Program
Monterey, California, U.S.A.

Comment: Thank you very much for your expert opinion and extremely timely response! I greatly appreciate your time and expertise.


  1. Hi this is good to read but also frustrating. I've had 1 failed round with 2 folicles 1 egg retrieved and am in my 2nd round buy looking like it's failed. I had only 1 large file but 4 tiny ones. They ignored the large 1 and nothing has happened with the small ones, which was gbd same ax round 1 for my smaller ones. I'm on day 12 tomorrow and my 3rd and final scan most likely. I feel I've been failed. I'm 40 and my husband and I agreed from the outset we wouldn't go down egg donor route. So tomorrow likely end of our road.

  2. Hello Dr.Ramirez,
    Iam 42, I was priming with Estrace and HGH Omnitrope for 30 days in May, and LDN, but June cycle was canceled due to high Estradial, cyst,n endometrioma. I remained on HGH only. I did not take Estrace nor BCP till next cycle and in July the same picture. Had surgery Lap/hyst, doctor removed Cyst, endometrioma, the rest of swollen remaining Fallopian tubes, scar tissues on ovaries, uterus. Still remained on HGH in July. This months I havent had new cycle started yet, today is CD 36. Estradial on 08/07 was 1240 and I have a new cyst! I was instructed to take Ganirelix for 5 days to suppress the cyst and lower Estradial. Estradial on 08/11 is 219. Today I was instructed to start stimms: Gonal 450, Menoupr 150, HGH 6units, ZPack, Prednisone 5mg 2x day(is it a good dose?), In my previous June and July canceled protocols I had Lovenox and Letrozole but they said I do not need to be on them. Doctor confirmed I do not need them. But I really think it is necessary for me to start them along with other stim drugs. I had 5 failed ivfs in last few years. And, 3 failed before I got my daughter, she is 8 years old now. Should I still take Lovenox and Letrozole? I must say I will do fresh transfer. Also,Im still on HGH 6 units and LDN since May. (1)I am worried Im on HGH for a long time).
    Thank you,



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