Tuesday, February 23, 2010

Off Depo Provera But Still No Period, What's Wrong?


Question:

Hello, I am 30 years old and was on the Depo-Provera shot for 3 years during which time I did not have a single period. I had my last shot in January 2008 and still have not had a period. My husband and I would like to start a family in the next 2-3 years and I am getting increasingly worried that this will not be possible. I am also suffering from very bad vaginal dryness (could this be related?)

I am currently doing some voluntary work in Argentina now and it is difficult to see an English speaking doctor. Is there something I can do to help my self in the short-term or should I consider returning home to seek medical advice?

Answer:

Hello T. from Argentina,

I am surprised that you can't find an English speaking doctor in Argentina. Maybe you should look for a Reproductive specialist specifically as most of them do speak English. If you still can't find one, then you should return to the U.S. for consultation.

Certainly, something is not working correctly which is preventing the ovary from ovulating, hence no periods. This is not due to the Depo Provera, since it does not last this long. It can delay periods for 1-3 months but not usually longer. There is something else going on and you need to undergo evaluation. The vaginal dryness is because you are probably not producing estrogen, which occurs with ovulation, and the vaginal gland is estrogen dependent. You don't want this to go on much longer because the vagina will actually begin to shrink and intercourse will be difficult and painful.

In order to get pregnant, depending on the cause of the problem, you need a treatment that will get you ovulating again. There are various options, but it depends on the cause. In the meantime, you might want to consider going on the birth control pill in order to get you cycling again (it overrides the ovaries so is not correcting the problem), which will give you estrogen. Many parts of your body require estrogen. You should be able to get this from a non-English speaking doctor while you plan to return to the U.S. for consultation.

Thank you for writing and good luck!

Sincerely,

Edward J. Ramirez, M.D., FACOG
Executive Medical Director
The Fertility and Gynecology Center
Monterey Bay IVF Program
www.montereybayivf.com

223 comments:

  1. I am actually researching a similar situation. I was on the Depo for almost 7 years. My last shot was January, 2009 and I still have not had a period. When I was in my teens, I had a very irregular cycle. It was sporadic, heavy, lasting weeks at a time and at times extremely painful. The doctors could not figure out what was wrong, so they put me on the shot to stop it. 'Out of sight, out of mind.'

    Now 24 and engaged, I'm worried that I may not be fertile or ever be able to have children. Everyone that I've seen seems to not have an answer for me.

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    Replies
    1. I am not a doctor, but I know for a fact that depo provera made it impossible for me to concieve on my own. I had the shot for three years and never had a period. Five years later I had periods but did not produce any progesterone ( which you need to ovulate.)I have two children now, but had to take clomid to concieve and progesterone supplements to support the pregnancy the first 12 weeks. I would see a fertilty specialist! Good luck!

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  2. The Depo should not affect your fertility, and I'm surprised you couldn't find an answer to your question.

    I don't think that Depo would have been my first choice when you were a teen. Irregular cycles are usually caused by an ovarian dysfunction, such as PCO, and can be easily controlled by birth control pills. It would also reduce the amount of bleeding that you would have each month. In addition, the severe cramping could have been a sign of endometriosis, which would have required a laparoscopy to diagnose. The good thing is that if this were the case, Depo provera is a good treatment for endo and can slow down its development, and hopefully, preserve your fertility.

    Once you come off the Depo, your ovarian function would return to its normal state. If that is a dysfunctional state, like before, then you would go back to having irregular periods. That means that in order to get pregnant, you would have to use a fertility medication in order to correct the ovarian dysfunction and get them to ovulate. If the severe cramping returns, you may have to undergo a laparoscopy to evaluate for and treat the endometriosis, since this can prevent pregnancy as well.

    You don't need to worry that you won't ever have children. Fertility treatment technology has greatly expanded and you have many options. I am sure there is an option that will get you pregnant. It will just be to determine which option is the best option for you. So, give yourself one year of trying to get pregnant, then if not successful, see a fertility specialist to undergo an evaluation leading to an appropriate treatment. If your cycles are irregular, then you don't have to wait the one year but go in as soon as six months. I have no doubt that in the end, you'll be blessed with children.

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  3. I am a 16 yrs oldand want to find the right birth control for me, I have been given the shot twice. When I stopped the first time my period went came for about 2 weeks snd I would only be off for 4 days. So I got the second shot.During that time I was seen by a Obgyn doctor,he told me that woman could only be on depo for 2 years because of the bone thining! Im almost due for my next shot and want to know if it's right for me.I also plan to have kids in my future! Pills don't work for me because I often miss days.

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  4. Hello. Your doctor is correct in that the manufacturer warns that Depo provera can lead to a loss of bone due to the lack of estrogen, which is required for bone formation. They also do not recommend continuation of Depo provera, unless there are no other alternatives, for over two years. Have you been on Depo for 2 years? If not, then you can certainly continue it. If so, then you should look at other forms of birth control. There are several methods besides the birth control pill that work well for teens. For example, you could consider the vaginal ring, which is used on a monthly basis. You should talk to your Gyn doc about the other options.

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  5. Depo provera is an excellent birth control method for teens because it is every three months and you don't have to remember to take a pill every day. However, your doctor is correct in that the manufacturer of this drug does warn that it can lead to bone thinning. This is due to a lack of estrogen, which is needed to help with bone growth and maintenance. For this reason, the manufacturer does not recommend using Depo beyond two years unless no other method is available. One way to overcome this, however is to use a little estrogen replacement in addition. You should have a good talk with you Gyn regarding other methods of birth control. There are more methods than just the pill. For example, there is a vaginal ring that only has to be replaced once a month.

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  6. I am 27 and have been on Depo on and off for 8 years. I never got my periods. My last shot was due 6 weeks ago and I still have not gotten my periods, is this normal?

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  7. This can be normal. Depo provera can linger, leading to a lack of ovulation and therefore a lack of menses. You should get a period within three months, however. In the meantime, instead of waiting for your periods to start, you might want to visit your doctor and have him/her get it started for you.

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    Replies
    1. How can my doctor "get it started" for me? I was on Depo for approx 3 years and my last injection was approx 6 months ago (so now 3 months since the last one was due but not given) and have not yet got my period back & my fiance and I are very keen to start trying to concieve.
      Thanks in advance
      Brenda

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  8. I was on the shot for 4 years. 6 months after my last shot I had surgery to remove cysts from my ovaries, 7 on my right one and 5 off the left one. 2 weeks later, my ovaries were covered again. My OBGYN told me that depo was my best option to keep the cysts away, so I went back on it and continued to get cysts regularly every month, sometimes twice a month. Never had a period. I was on the shot for 3 more years with cysts every month, I was told there was nothing better to help, when the studies were done about the bone loss and sure enough at 23 I was diagnosed with Osteopenia and came off the shot. 4 years later after trying many other methods that did not help my cysts and irregular periods I decided to go back to the shot, but I only got it twice. During those 6 months I spotted the entire time, and of course still had cysts. It's been a year since I got the shot and I haven't had a period (or any spotting) in 9 months, and of course-still have cysts. Should I just stay away from bc and deal with the cysts or is there anything else that doesn't have bone thining side effects and will help control cysts (which have always been worse off the shot)

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  9. You need to come off the Depo provera. I'm not so sure about the diagnosis of "cysts" in the ovary. I have NEVER heard of anyone taking out more than one or two cysts per ovary. Taking out "7" and "5" sounds very very suspicious to me. Also, Depo prover works by suppressing the ovaries. It is absolutely NOT possible to form cysts while on Depo provera unless it is some kind of tumor. For those reasons, I am very very skeptical of your diagnosis. Was your doctor calling follicles cysts? Follicles are normal in the resting ovaries and often seen in young patients. Certain types of patients have more follicles that others, such as patients with polycystic ovarian disease. That is a characteristic ultrasound finding in these types of patients. These follicles are NOT pathologic. They do not cause disease and DO NOT need to be removed or suppressed.

    My recommendation would be to go see another doctor, have an ultrasound performed and get another opinion. I am doubtful about your first doctor's opinion. The only cysts that need to be treated and suppressed are cysts that grow to more than 2.5 cms. It is is less than that, leave it alone. If you are getting cysts larger than this on a regular basis, then it would be a good idea to suppress them if they are not resolving on their own (most benign cysts are physiologic cysts and resolve on their own) with the birth control pill, NOT depo provera. Depo can be used, but as experienced by you, prolonged usage can have long term effects. Birth control pills are better because they suppress the ovaries (hence the cysts), yet have estrogen so that there are not the effects on the bone.

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  10. I've had problems for years with getting pregnant. I'm 32 and was on the Depo shot in my late teens. I went off the Depo shot and did not get my period for a year. I then went to my obgyn (I was 19 at this time) and she ordered some tests to be run. They did a CT scan on my head and found a tumor in the petuitary gland. I'm surprised that you are not advising these females that are looking for advice and answers that this is something to ask their Dr. about. This can be a main cause of not getting pregnant due to high prolactin levels, which will require fertility drugs.

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  11. Hi and thanks for the comment. In fact, if a patient does not have a prolonged period of time without a period, the standard practice is to do a hormone panel which checks for FSH, LH, Estradiol, Prolactin and TSH. This checks the hypothalamic- pituitary - ovarian pathway and thyroid functions. Unfortunately, not all general Physicians or Ob/Gyn docs do this. In my blog I generally recommend that patients seek a consultation with a specialist. They would know to check these.

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  12. I only got the depo shot a few times, and after that, I decided it wasn't the right method for me and I immediately went on the pill and have been taking it every day. I am still sexually active and we always use condoms. But I was wondering, I still haven't gotten my period yet. Should I take a pregnancy test? Or is this normal? Also, I was thinking of switching to the IUD, but would that be harmful to my body to keep switching methods? Thanks so much and hope to hear from you soon!

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  13. I was advised to have the depo shot, as a once off as i was being tested for a protein c deficiency. how ever that came back negative. my periods had not returned, my gp ordered test, said i have a hormone imbalance, have started lactating, only minimal,weight gain, migrains. i am currently taking duphaston, for 10 days only. i still have no signs of my period.i have been tested for preganancy which was negative. if i am put back on the pill will this return my periods?

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  14. Both of these got published at the same sitting so sorry that this response is not strictly individualized. So here's my comments to each of the anonymous comments.

    To the September anonymous, you can certainly change birth control methods as much as you want, there is not harm to it, as long as you are not changing them mid-stream. That is, with any of the hormonal methods, if you stop it without fininshing the cycle, such as with birth control pills, you may end up with abnormal bleeding problems. With depo it doesn't matter if you stop before the 3 months is up. In terms of not having a period, the effects of depo can certainly linger for 2-3 months, but that does not necessarily rule out a pregnancy, so certainly you should have a pregnancy test.

    For the October anonymous, your question is not clear what is going on, but I certainly don't understand why your GP has not referred you to an endocrinologist or reproductive endocrinologist. These are the specialists in hormonal and menstrual disorders. I can't even figure out how a protein C test comes into play. You mention that you have some breast milk production which could be a sign of a prolactin or pituitary disorder. That needs to be investigated and if present, treated appropriately. The worst thing you can do is just go on the birth control pill without knowing what is causing the problem. The BCP will just mask the problem and the problem may not be solved nor be treated appropriately.

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  15. Arlington Tx

    Hello I rencently had twins and in September 17 my doctor gave me the shot then on the 30th I had my tubes tied. all of October I had a regular cycle then it just stopped, Up till now I haven't had a period at all. Now I'm worried my system is thrown off. What should I do to get it back on track.

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  16. Part of the way Depo provera works to prevent pregnancy is to inhibit ovarian function for at least a three month period. So your ovaries have shut down as a result of the depo and this will last for at least a 3 months period but it may take 4-5 months before your ovaries reset and you start cycling normally again. The only way to have regular cycles at this point would be to use a low dose birth control to artificially give you a period each month. I would recommend that you not worry about it for now and just wait for the medication to wear off.

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  17. Hi, I was on the depo shot for years and got off when we decided to have a baby. My period came back in 3 months and we got pregnant the next month. After my son was born I went back on the depo shot and have been on it for 3 years. I have now stopped taking the shot and it has been 4 months and I only had a little bit of spotting for a few days last month and now nothing. I know it could take a little while for my system to become regular again however the last time I went off of the shot we had no problems getting pregnant very quickly. I am worried now that this time will take a lot longer. Is it too early to talk to my doctor about why my period is not returning? I have taken a preg test and it was negative.

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  18. Hello,

    Sorry for the delay in getting back to you and posting your question. I have been away for several days.

    I think that you are definitely at the point that necessitates that you speak with your doctor. It can take a while for the ovaries to resume function after depo provera, but the ovaries can also have other problems not related to this medication that is preventing it's function as well. Some times the ovary needs a little "kick start" to get it functioning again. Certainly, if you want to get pregnant sooner than later, fertility medications can be used to get the ovary ovulating so you have that opportunity. Your doctor should be able to explain what needs to be done and what all the options are.

    Good Luck

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  19. Dear Dr. Ramirez-
    My situation is a bit complicated, I will do my best to summarize.

    I started my periods when I was 11 and from the start I had very heavy bleeding and pain with each cycle. I went to the doctor at 14 to see if there was something wrong. I was not anemic, but they did other tests and diagnosed me with Von Wilebrands Disease. I was put on the pill but within a few months developed hard lumps all over my legs. After a biopsy, I was diagnosed with Erythema Nodosum, a reaction to the estrogen in the pills. I went off the pill, the doctors thought the hormones might have regulated me but they didn't. So in order to control the bleeding they put me on Depo Provera.

    I have been on Depo Provera since I was 14 and am now 28 years old. I have never missed a dose of Depo that entire time. During the first year I spotted, but after that have not had a period since. Only once, have I spotted since the first year.

    My concern is about my fertility after having been on the Depo shot for 14 years. I have seen many websites where people blame their infertility on the Depo shot. I don't plan to become pregnant anytime soon, but I still fear for my fertility when the time comes. Is there any way to test my fertility now to begin taking action if necessary?

    Thank you for your time!

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  20. Hello,

    There is no one test that can be done to test infertility. Infertility tresting is actual several tests that look at each step the body goes through to achieve pregnancy.

    Depo provera has not been associated with a decrease in infertility, and you can't trust a lot of what you read on the internet, so at this point I would not worry unnecessarily.

    Good Luck

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  21. I went on the Depo in 2002 and went off in 2007 or 08 and now it's 2011 why haven't I had a period I have been tested and everything and all the test came back fine so I want to know from you what should I do now.

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  22. Hello,

    The depo provera would have worn off a long long time ago i.e. 2008 so your lack of periods is not due to that medication. You state that your testing was "normal", but I am not sure what that means. FSH/LH levels could be within the normal laboratory range and still be clinically abnormal. Without seeing the exact numbers, it is hard to interpret. I am sure, however, that there is some type of ovarian dysfunction occurring and as a result, you are not ovulatory. If you have not had a hormone panel done already, then you need to have one done. These tests include FSH, LH, TSH, Prolactin and Estradiol. I would recommend that you take Provera 10 mg per day for 5 days to induce a menses then have the tests done on the second or third day of the bleed. If you don't have a period after one week from the last Provera tablet, then you would take a birth control pill pack (30 mcg estradiol minimum) for one cycle, then you should have a period.

    With this history, if it is found that the problem is in the ovary and not the hypothalamus, pituitary or thyroid, then you have a choice. If you are not wanting to get pregnant, then you would go on the birth control pill to regulate your cycles and replace the hormones your ovaries are not producing. If you want pregnancy, then you have to undergo ovulation induction in order to get the ovaries to ovulate.

    Good Luck.

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  23. Hi! I went to depo for i have a short memory remembering my pills everyday. Had taken 3 shots on depo. I was scheduled to go back last January 5,2011 for my 4th shot but did not come back for i have been gaining a lot of weight. I have read online that you can take pills but has to be taken when your next shot should be due and so i did. It has been 3 months since i switch to pills but still did not had my period. My pills is a progestogen pills for i am still breastfeeding my 3 yr old daughter. What do i need to do so i can have my period back?

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  24. Hello,

    The reason you have not had a period is because you are taking progesterone only pills. Your doctor gave you this because you are still breastfeeding. In order to have a period, you have to have estrogen. The estrogen then builds up the uterine lining. Then at the end of the cycle or pill, the hormones drop off (if you don't get pregnant in a natural cycle), so the lining sloughs and you have a bleed.

    If you are artificially preventing the lining from developing, then it is not necessary for you to have a period, so we don't consider that a problem. If you want to have periods, and not get pregnant, then you would have to take a birth control pill that has estrogen in it. However, if you do that, there is a possibility that it will stop your breat milk and you will have to stop breastfeeding.

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  25. Hello,
    I recently turned 35 and have been trying to conceive since Jan 2010 without luck. I have a 3yr old son (1st pregnancy) who was born by caesarean section in Jan 2008 and was conceived naturally without any effort at all. I started on the depo for the first time in Feb 2009 through to Sept 2009. Between coming off the depo (Sept 2009) and to date my periods have been very irregular sometimes going 2-3 months without a period or having 2 periods within a space of two weeks. I assumed this was just my body still trying to get rid of the effects of the depo as I'd been advised at the time of my first shot that it could take up to 18months after my last shot for my body to be completely rid of the effects of the depo. Having now tried for over a year to conceive, I started seeing a fertility specialist about a month ago who undertook blood tests. She recently informed me that the results of one of the tests (AMH) revealed that I have very low ovarian reserve, infact similar to that of a 40-year old woman, which may be the cause of my irregular periods and lack of ovulation. She also said that owing to the very low ovarian reserve she would not advice IVF treatment as the chances of success would be almost zero. She's arranged for me to undertake a laparoscopy and hysteroscopy next week just to rule out any further fertility issues such as blocked tubes.
    I'm completely at loss with the news of my low ovarian reserve particularly as before and soon after pregnancy, my cycles were like clockwork (27days exactly) and I knew exactly when I was ovulating and the exact day each period will start. Also, the time I was on the depo was the only time I ever used any form of contraception other than condoms. However, ever since coming off the depo, my body feels like it belongs to someone else and unable to tell when/if I’m ovulating or when to expect my periods and how long for. I'm starting to believe that the depo had something to do with my irregular cycles (even though you say the effects don’t normally last longer than 3/4 of months) and my abnormally low ovarian reserve. I would also appreciate your advice on the best course of fertility treatment for me. My specialist has suggested continuing trying to conceive naturally for now and has prescribed Clomide (50mg for 5 days from cycle day 3) and progynova (2mg for 10days from cycle dy 10). She’s also prescribed provera for use if there is no period.

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  26. Hello,
    I apologize that this comment is getting posted so late after yours. This is the fourth time I am trying to post a response over this past week. I hope it works.

    I am in disagreement with your doctor over the interpretation of the AMH. A low AHM certainly indicates that there may be a reduction in the number of eggs available, but neither it nor the other indicators of "ovarian reserve" can tell how the quality is. Remember, it only takes 1 good embryo to be successful. I disagree that you should move to Clomid. That is illogical to me. Considering that you may be running out of eggs (as indicated by the AMH), why would you try the treatment with the LOWEST chances of success. I think you need to be aggressive! IVF is your best treatment option.

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  27. Yay it posted! I'm sorry it is shorter than usual because I was thinking that might be the reason it didn't post. So here's part two of my answer.

    In answer to the Depo provera issue, it has nothing to do with the AMH. Also in terms of the AMH, it is an indicator of how your ovaries might respond to stimulation, just as the CD#2 or 3 FSH, Clomid challenge test and antral follicle count are. It is NOT a measure of the quality of the eggs remaining. There is no test for that currently. Considering you are still young, I would still expect that even if you did not stimulate well, the few eggs retrieved that made embryos would have a good chance of leading to a pregnancy.

    In terms of IVF vs Clomid, why would you want to do a treatment that only gives you a maximum of 12-20% chance of pregnancy per cycle (IUI) versus one that would give you a 60-70% chance per cycle, and with IVF you really only want to transfer 1-2 embryos anyways.

    Good Luck.

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  28. Here's part three.

    Forget the laparoscopy because you don't need it with IVF and it is a surgery (rather invasive) but the hysteroscopy is okay because you need that with IVF.

    AMH is NOT an indicator of ovarian function and is NOT the reason for your irregular cycles. It is an indirect measure of the number of eggs remaining, but not an exact measurement.

    It does not sound like you are seeing an infertility specialist because she is giving you false information. Maybe she is not recommending IVF because she doesn't offer it? I would recommend that you go see an Infertility subspecialist for a second opinion before proceding further with this doctor. . . preferably one that can offer you all levels of infertility treatments including IVF.

    Again, Good Luck.

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  29. Hi, I recieve my last Depo shot in March 2010 but approx. in July or Aug. I began to spot reguarly and sometimes it would be brown. In Jan.2011 my period fianlly came but it hasn't come on since. My GYN says that its due to the shot but I have my doubts. I had an pelvic & vaginal ultrasound done for the pelvic pain I've been having for almost a year but it came out normal. Could it possible be any other reason???? PLEASE HELP, SO FRUSTRATED!!!

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  30. Hello,

    The depo provera should have worn off by now so I don't think that is the reason you are not having periods. There is probably some other source, like an ovarian dysfunction disorder. You should have a pregnancy test done first, and if negative then take Provera (or equivalent) for 5 days to start a period. On the second or third day of your period, you should have blood testing for FSH, LH, Estradiol, TSH and Prolactin. Further evaluation and/or treatment will depend on these results.

    In terms of the pelvic pain, that is another issue entirely. If the ultrasound was negative, then the next step I would recommend is a laparoscopy. This is an outpatient surgery to look inside at the pelvis. The most common finding would be endometriosis, which should be diagnosed and treated appropriately. Endometriosis is the second most common reason for hysterectomies at a young age (under 40) and one of the top causes for infertility. It is best to be treated early for these reasons.

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  31. Hello iam 32 years old i took the depo shot in November 2010 it is now May 2011 and i still haven't got my period i took 3 pregnancy test within the last 3 months and the have come back negative, but my breast are tender and producing some brest milk. Its that normal??? or should i be worry about it??? any suggestions would be greatly appreciated.

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  32. Hello,

    By now your cycles should have resumed so there is something going on but it is not due to the Depo provera. With the breast milk production, I would be worried that your pituitary hormone (prolactin) is elevated and this would cause the menstrual problems. This needs to be evaluated because sometimes there can be a tumor causing this. I would recommend that you see your Gynecologist or an Endocrinologist.

    Good Luck.

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  33. Dear Dr. Ramirez would the pituitary hormone being elevated also have something to do with weight gain?? i gain little more than 20lbs since the depo shot and despite any diets and excercise i cant get rid of it.
    Thanks

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  34. Hi, My last shot was in November 2010. I still have not got my period.My husband and I are TTC.I went to the dr because i'm cramping and my back hurt. They took blood work and They said that my Hormone levels were normal. He wants me to do go to obgyn because he not sure why I haven't started my period. I'm worried, why haven't I started my period if my hormone levels are normal,

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  35. Hi,

    There are other possible reasons if all the hormone levels are normal. You need to see an Ob/Gyn and go through a full evaluation to determine the exact cause. The most common cause is an ovarian disorder called Polycystic Ovarian Disease, but there are other reasons as well.

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  36. Hello Weight gain question,

    It is possible that an elevated pituitary level would influence the thyroid hormone which affects your metabolism. This could lead to an increase in weight gain, but I would not jump to that conclusion as yet. Weight gain in the majority of cases, is due to increased calories in and decreased calories out.

    Good Luck

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  37. I had a depo shot in February 2011 had no cycle in march 1 in April and none in May, could I be pregnant?

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  38. Hello Dia's Lashes,

    Pregnancy is always a possibility but I would not put it high on my list. Depo provera could certainly have lingering effects that last for more than the three months between injections, and in your case, you are not beyond the three month period. If you had the injection on February 20th, this month would be three months on May 20th, so the Depo provera effects would definitely still be in place. Remember that Depo provera is a contraceptive and purposefully shuts down the ovary so that you don't ovulate and therefore don't get pregnant.

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  39. Hi..I had a depo shot in nov. 2010 my last shot was going to be in feb 2011 but didn't go back to many side effects been on the pill since april 2011 jus finished my first pack a few days ago and didn't have a withdraw bleed...would really like my third child soon...never had any problems befor with my periods...should I. Continue my 2nd pack until I get my cycle or just get off and wait it out....is there anything I can take to better my chances getting rid of depo starting my cycle ovulating....thanx in advance

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  40. Hello Juanita,

    The Depo provera injection/medication can sometimes last for more than three months, up to 5 months, but by then it should be out of the system. So by now you should have had a period, and considering the fact that you took a birth control pill, that overrides everything so it should have induced a period on it's own. The fact that there was no withdrawal bleed means that you were probably on a very low dose BCP that did not have sufficient estrogen to induce a bleed. My recommendation would be to either go off the pill completely and wait until your cycle starts, and if it doesn't within two months then you need an evaluation to find out why, or take a BCP with a higher estrogen dose (at least 30 mcg) for one month to have a period then go from there.

    Good Luck

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  41. Hi im 31 years old and had 2 children and came of Depo in October last year because of bloating (the depo was not the cause as I had this symptom before) & decided to clear myself from any medications) I have not had a period since, I seen my GP with regard to the bloating where she found blood in my urine so sent me for an ultrasound which had showed to be a cyst in my kidney, I was assured there was nothing to worry about, I saw my GP again a month later where she still found blood in my urine so sent my for a cystascope,--everything was fine with that, and blood tests were fine too, I believe they were liver function tests, full blood count and Thyroid. I have now noticed a pain in my left groin which is intermittent during the day what I can only describe as a wave of pressure, Is this related to my problem? Should I be concerned that I have had no period yet, and the new symptom of groin pain? Another thing I would also like to mention is I have no libido what so ever.
    Lisa.
    Scotland u.k

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  42. Hello Anonymous 31yo,

    It is highly unusual for you not to have a period for such a long period of time after stopping Depo provera. There is some type of ovarian dysfunction going on. I cannot relate this to the groin pain you are having, however. I would recommend that you see a gynecologist for further evaluation.

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  43. Hello,
    I just got off of the depo shot on the 15th of June of last month after being on it for two years. But two week ago I started having cramps in my lower part of my stomach, pelvic and lower back pains with no period. And I took a dollar pregnancy test but it was negative. I was just wondering if it was a withdrawl for not having the depo shot. Thanks

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  44. Hi,

    I'm afraid I can't answer this question. There are too many unknowns and there is no "withdrawal pain" from depo provera. Sorry I can't be more help. If the pain continues, then you should see your gynecologist.

    Goof Luck,

    ReplyDelete
  45. I was on depo for four years. My last shot was October 2010. I had a cycle in February but I haven't had one since then. I haven't had any spotting. And while I was on da shot I had only 4 periods and I went two of those years without a period. I gained 40 pounds while on the shot. I exercised and ate healthy and I still gained weight. Now that I'm off the shot I still can't lose the weight. What can I do to lose weight and get my cycle back to normal?

    ReplyDelete
  46. Hello Deshae,

    It has been way too long to still be having effects from the Depo provera. You ovary is not functioning for some reason and may be the reason for the weight gain. There is a disorder called polycystic ovarian disease (PCOD) which I also talk about extensively in this blog, that is an ovarian dysfunction leading to a hormonal imbalance and often leads to weight gain. My recommendation would be for you to go see a Gynecologist for evaluation and appropriate treatment.

    Good Luck

    ReplyDelete
  47. I had my first chil june 2010 after depo, then strated depo again july of 2010. I want another child so last shot was jan 2011. Still have not had a cycle and even took provera. Nothing have lower abd. cramp and pain in abd, tender breast, elevated temp. but no menstural cycle. could i still get prgnant and what is happening.

    Amanda Lawson
    30yr mothe of one

    ReplyDelete
  48. Hello Amanda,

    There is a small chance that your ovaries could turn on and if you have intercourse at the right time in that cycle, you could get pregnant without having a period. So, as long as you don't have a period, you need to have a pregnancy test checked.

    If you didn't have a withdrawal bleed with Provera, then a blood pregnancy test should have been checked. If it was negative, then I would use a low dose birth control pill, three times per day for one week to cause a withdrawal bleed. That basically confirms that you did not have an adequate endometrial lining to cause a bleed after the Provera.

    From that point, if you are interested in getting pregnant again, you would need to go on some form of fertility medication to get your ovaries to work (ovulation induction). There are various medications. If you use these meds for 1-3 cycles, then the ovaries should kick back in themselves, hopefully.

    By now, the Depo provera should have worn off, but sometimes can last a little longer. If you did not have any ovarian problems prior to the depo provera, it should return to normal. If you had irregular cycles before the Depo, then you will go back to having irregular cycles again, in which case the fertility medication will be required to help you to have regular ovulation.

    Good Luck,

    Dr. Edward J. Ramirez, M.D., FACOG
    Executive Medical Director
    The Fertility and Gynecology Center
    Monterey Bay IVF Program
    www.montereybayivf.com

    Monterey, California, U.S.A.

    for additional information check out my blog at http://womenshealthandfertility.blogspot.com check me out on twitter with me at @montereybayivf and facebook @montereybayivf

    ReplyDelete
  49. I have been on Depo for 9 years. I just got off of it 2 months ago. I have horrible pelvic cramping and pain, and it's worse at night to the point it wakes me up. This has been going on for 2 weeks now. My boob's were tender too for about a week, and now I have horrible lower back pain. I was just wondering if it's normal? I still haven't gotten my period yet either.

    ReplyDelete
  50. Hello,

    Your symptoms are not related to Depo provera. I would strongly recommend that you go see your Gynecologist for an evaluation. These symptoms are not normal.

    ReplyDelete
  51. I've been on Depo for 2 years and was supposed to get a shot this past Aug. My husband and I are trying to conceive and I want to know how long will it take to get the Depo out of my system? Do I need to do anything to try and conceive or just let things happen on its on? Please help!

    ReplyDelete
  52. Hello Sept 25th,

    It can take a little while for the Depo to get out of your system... anywhere from 6-10 weeks from when the last one was due. I would recommend that you wait for your cycles to restart then you can time when to have intercourse to achieve pregnancy. If you don't have a period by November, then you should see your gynecologist to get your cycles going again.

    Good Luck.

    ReplyDelete
  53. I am now on depo and my period just wouldn't stop. I am 41yrs old and a mother of 3 grown kids. Please tell me if there's a way to stop the excess bleeding which is going on to one month now non stop.

    ReplyDelete
  54. Hello,

    A very common side effect of Depo provera is dysfunctional uterine bleeding in the first and possibly, the second cycle. After that the bleeding will stop completely and you won't have periods any more. Usually the Depo is give with the onset of her period so that there is very little endometrial tissue present, which reduces this bleeding. If it was given later in the cycle (like middle to end), there could be a build up of endometrium which would lead to bleeding.

    However, I would not assume that the bleeding was from the depo and since it has been going on for a long time, you need to see your gynecologist and have an evaluation done. There are other sources of bleeding such as polyps, endometrial hyperplasia and endometrial cancer that need to be ruled out.

    With dysfunctional bleeding, it can often be controlled by adding back a little estrogen.

    Good Luck.

    ReplyDelete
  55. Hello,

    I started on depo provera when I was 21 in 2010, I came off it exactly one year later in February 2011. While on depo provera I did not have one period. It has been 9 months and I still have not had a period except the odd bit off spotting, but barely even noticable. I am concerned about my fertility, and is this normal after dep provera.

    ReplyDelete
  56. Hi,

    Your lack of a period 9 month out is not due to the Depo provera. Something else is going on that is preventing your ovaries from functioning correctly and ovulating. You need to have an evaluation done. If pregnancy is your main interest at this time, you could proceed directly to ovulation induction, where fertility medications are used to stimulate the ovary to ovulate. Make sure you see a doc that knows what they are doing.

    ReplyDelete
  57. I RECEIVED THREE DEPO SHOTS. MY LAST SHOT WAS IN JULY OF 19. I HAD A PERIOD IN SEPTEMBER. IT CAME ON TWICE, STOP AND NEXT SPOTTING ROUND THE END OF SEPTEMBER. I HAVE NOT HAD A PERIOD SINCE THEN. NO PERIOD IN OCTOBER AND NO PERIOD YET FOR THIS MONTH OF NOVEMBER. COULD I BE PREGNANT? I TOOK A HOME PREGNANCY TEST. THERE WAS TWO LINES BUT THE OTHER LINE WAS FADED LIKE. I BEEN TRYING TO GET PREGNANT SO MANY TIMES AND I NEVER THOUGHT I COULD HAVE CHILDREN. BUT CAN I BE PREGNANT NOW?

    ReplyDelete
  58. hi,

    mabuhay...
    i'm 7days delayed of my regular period.this is the first time happen to me ever since.im married with 2kids repeat CS..i took pregnancy test 4x but the result still negative.i was so stress afraid of having a baby not on a plan..my husband and i using calendar/ovulation calendar method.it's almost 4months my last take of contaceptives (pills) .before i came to my OB i was injected with(depo trust) even i missed my period.and i was not able to confess or tell to my OB.and my OB give me Duphaston and instruct me to take 2x a day for 5days cause my ultrasound (TVS) result was ''follicles noted on each ovary''(multiple immature subcapsular)...can i take the duphaston while im on Depo?thank u... i'm fervently hoping for your reply

    ReplyDelete
  59. Hi Dr Ramirez

    I have been off the injection for 16 months now and still no period.
    I have been having pain in my lower left and right ab, we are ready for a baby now but am just confused I don't know if I will get pregnant or if its a waiting game.
    My last Dr gave me Norethisterone to bring back my period but I haven't been taking it cause I don't want to bleed for a long time I don't know HELP please.

    Diane

    ReplyDelete
  60. Of course pregnancy is always a possibility if you are not using any birth control. Having an ovarian dysfunction and missing periods does not entirely preclude pregnancy because one of those cycles could be an ovulatory cycle. The only way to find out for sure is to have a blood pregnancy test.

    ReplyDelete
  61. Hello Mabuhay,

    If I understand you correctly, you took a Depo provera injection, which would stop you from having periods. Therefore, not having a period should not be a problem. I dont' know why your doctor did not just reassure you that this was normal and instead chose to treat it. The ultrasound findings are not signficant and are normal findings.

    ReplyDelete
  62. Hello Diane,

    The Depo provera has worn off by now and is the not reason that you are not having a period. You have some type of ovulation disorder going on and that needs to be checked. Considering that it has been so long since you had a period, the birth control pill is the right treatment and necessary. You are right that it could cause a heavy bleed but it is neceesary. Once you have had a period, you should have a hormone panel checked to see why your are not ovulating. Then the treatment will be determined based on what needs to be treated. In general, you should not go more than three months without a period if you are not on birth control pills or Depo provera.

    ReplyDelete
    Replies
    1. Hello Dr. Ramirez

      I have good news for you am 6 months pregnant and very happy thank-you for your help.

      Delete
  63. Hi! Im 23 years old and I have been on and off the depo shot for 5 years. I had my last shot in April 2011 and I was supposed to go back in July 2011 but I didnt. It has now been around 4 months since Ive been off the shot. My breast have been really sore and last week i found my self lying on the floor and unable to move from severe cramping. I am really worried because usually when I miss my depshot i get my period a month later..... now i may spot for a day but that rarely happens not to mention I found out I had HPV from my ex-boyfriend of 8 years. Any thoughts on that.By the way I havent been sexually active for 8months.Could Hpv have something to do with all this chaos ? Im really nervous.

    ReplyDelete
  64. Hello Nov 23 Anonymous,

    It is not unusual to have a delayed period with Depo provera that can last up to 6 months, but if you have had some spotting, that may be your period. Since the Depo prevents an endometrial lining from developing, there is usually not much to bleed until your ovaries become functional again.

    The HPV has nothing to do with the symptoms that you had. However, HPV is a sexually transmitted disease and if there is one, there is the possibility of others such as Chlamydia, Gonorrhea or Syphilis, amount others. You should get checked. In the acute phase, some of these can cause pelvic pain.

    ReplyDelete
  65. Hi Dr Ramirez

    I took your advice and went to see a gynecology and he gave me Loestrin* 30 tablets.
    I have took take it for 21 day's then 7 day's break, I have to do this for 3 months so hopefully I at the end of this first pack I should have a period, or a miracle to wake my lazy ovaries as the doctor stated, so I look forward from hearing from you, by the way I didn't take the norethisterone that they gave me does it make any different now, as am drinking the new pill that I got from the Gyne Dr.

    love Diane

    ReplyDelete
  66. Hello Diane,

    Thanks for the love and back to you.

    You don't need the Norethindrone if you are taking the birth control pill. It already has progesterone in it (the same as Norethindrone).

    Like I mentioned before, you have some type of ovarian dysfunction going on. Taking the pill might not resolve it (there is no such thing as a "lazy" ovary), but the treatment with BCP's is correct until you decide that you want to become pregnant. Then a different treatment may be required.

    Good Luck,

    ReplyDelete
  67. Hi Dr Ramirez

    It's me Diane again just to let you know that I have started my period and I have stop taking the pill I hope it's a good choice I have made as I wanted to get my period back so that my body will go back to normal, so for now am just gone a live it with time and make nature take it's course so I shoukd be preggers sooner rather than later, Lol.

    Am very happy to have found this web page so that I can speak to a great person like you.

    All my love and prayer goes to you and your team
    Thanks a bunch.

    Love

    Diane

    ReplyDelete
  68. Hello,
    I have been on the Depo shot for a few years. I got off the shot in January and it being December i still have not had a period. I god blood work done but they told me it would not be back till next year. I was also told i cant go back on a birth control method until i get my period. I am sexualy active and last night i our condom broke. I went and and got the plan b pill just to be safe but is it possible for me to get pregnant? and if so do you think i have a grater chance with this plan b? also, if i havent had my period in months, if i wait a month to take a urine test will it work?

    ReplyDelete
  69. I don't think that the reason why you are not having periods has anything to do with the Depo provera. By now, those effects should have worn off. It is possible that there is some other type of ovulatory dysfunction preventing your cycles. The proper treatment would be to cycle with the birth control pill if you are not trying for pregnancy.

    This also means that you are not ovulatory but it is not possible to predict when your ovary will start back again and usually ovulation will precede the first period. So yes, there is a possibility that ovulation may have occurred leading to a pregnancy. By taking the Plan B, that should prevent a pregnancy from occurring. You may also find that you have a bleed as well since the birth control pill tablets (plan B) may induce it. If you don't have a spontaneous period then you should probably do a pregnancy test, but wait until at least two weeks.

    ReplyDelete
  70. I was due for my depo shot on June 30th. I was unable to get it and ever since i havent had a period. I also noticed am still gaining a lot of weight. I really want to start a new year with a new me by loosing weight and beng healthy, but i also dont want to get pregnant. I am unsure of trting to get the shot again cause am trying hard to loose weight. What can i do?

    ReplyDelete
  71. I'm 25 and I have daughter that will be 6 in feb, 2012. My dr put me on the depo shot during my 6 weeks check up after having her. I took it faithfully every 13wks and had to come off of it the end of 08 begining of 09 due to finances. During this time my cycle never returned and in June 2009 went back on it. July 2011 it was due and I choose not to get it because my husband and I were ready for another child. My cycle returned 12-28-11 and was normal lasted for 4.5 days.

    Before getting pregnant with my daughter I had only TWO cycles my whole life one when 16 and like to bled to death the other was May 05.
    During the time that I have been on the shot I was diagnosed with Lupus, Fibromyalgia, RA, and early ostioperosis. What are my chances of the shot having this effect on health problems and chances of having another child?

    ReplyDelete
  72. Hello,

    I started depo November 08, I was on it for one year during that time I gained a total of 60 pounds along with horrible headaches so when my one year anniversary came around I decided to take a break give my body a break. During the course of the depo injections i did not have a period, when I came off I didn't recieve a period. I went to my
    obgyn and was told it could take as long as 6 months to a year. During that time I recieved one period. I reluctantly got back on depo for 6 months I have been off of depo since November 09 I have since recieved a total of maybe 3 to four periods all only like two days in length.. my concern is maybe I have messed up my system ? Is there something I can take over the counter or via prescription that would return my period

    ReplyDelete
  73. This comment has been removed by a blog administrator.

    ReplyDelete
  74. Hello Dec 30th,

    By now, the Depo effects should have worn off so that means that there is some other problem preventing the return of your cycles. More than likely it is an ovarian dysfunction, such a PCO (which can cause weight gain as a side effect), but there are other hormonal problems that it could be as well. I would recommend that you see a reproductive endocrinologist or gynecologist to have things checked out.

    The usual treatment depends on the problem. For PCO, the birth control pill is usually the treatment of choice to suppress the ovaries and balance the hormones (see my blog post on PCO).

    Have a Good New Year.

    ReplyDelete
  75. Hello January 2nd,

    The Depo effects should be out of your system. It seems that you had an ovarian dysfunction prior to even starting on Depo provera, as evidenced by the fact that you did not have regular monthly cycles. This is abnormal and your ovaries return to their preDepo state once the Depo is stopped.

    ReplyDelete
  76. Hi ive been off depo for about a yr now, been on it since 13, in 18 now, im having irregular peroids, some times early, sometimes late, my husband and have been tryi.g to.concieve, no luck.

    ReplyDelete
  77. Hello, I'm 20 years old, I have a son that will be 2 in July after I had him I got on the shot, which was in 09 at first my periods were long then they stopped... My last shot was July 2010 I was due for my next shot Oct 2009 I decided not to because I had started throwing up breast feeling funny nd just jot feeling good they said they were depo symptoms but I didn't understand why after a year I would get such symptoms... It's been three months still no period... Breast still feel funny. I had blood work and pee test they were negative but still feel pregnant. I want to have another baby but I am not having a period. I went to the doctor and she said I have fluid in my stomach they did x ray and seen that I had not drunk anything all day but I guess that explains why I see my stomach getting big... But I really want to kno when my periods will return. I have a doctors appointment with my obgyn Monday... I'm confused my body doesn't feel normal

    ReplyDelete
  78. Hello Jan 16,

    Your ovaries are not functioning normally. I cannot tell you why but that needs to be investigated. If pregnancy is desired then the ovaries need to be stimulated to function and ovulate. The exact treatment will depend on the problem. Make sure you see the correct subspecialist.

    Good Luck

    ReplyDelete
  79. Hello January 21,

    I'm afraid I cannot make a diagnosis through this venue. You will have to see an Ob/Gyn doc to find out what is going on. It certainly does not sound normal, and usually after stopping Depo provera, you period will start within 6 months so there is something else happening.

    Good Luck

    ReplyDelete
  80. Hey i was on Depo shot for a while. After i stoped i havet had acycle for the past 9 months or so. I went to go get checked but the docter said it was completely normal that sometimes it takes up to a year & am concerned because i gained a lot of weight and am trying to loose it so they were trying to get me back on on depo but i said no because of weight they recomened the IUD, but am nt sure what kind of side effects will there be? I havent had a cycle yet will the IUD help & will it prevent me from looseing weight what would you shugest?

    ReplyDelete
  81. I had my son 14 months ago. Soon after having him I decided to take depo provera when he was 4 months (March 2011) then again in June 2011 which was my last and final dose. Come end October I began to worry after not receiving a cycle. My obgyn gave me a pap which came back negative. I forgot to tell you hubby got fix in June. She gave me a pregnancy test and gave me hormones a 10 day and told me it should start a period around 2-3 weeks after stopping. So that would have been around mid November. Its now end January and still no period and I'm getting scared. So I called her last week and now she wants to try a 21 day hormone? I'm already over weight and have back acne that I cannot get rid of since. Never having ache before EVER. My weight is getting really out of control and I do not want anything else that can help with that. My questions are should I be worried about an absent period thus long? And can hormones be more harm than good?

    Sincerely lost

    ReplyDelete
  82. I have read each and everyones post... Everybody have had years of depo and are having problems... But I on another hand already have 3 kids working on my 4th... I never gotten birth control until having my 3rd child... I took depo twice meaning the total of 3 months last shot was June 23 2011 and now it has been the end of Jan 2012 no sight of my period.. I mean I have had 15 days of on and off spotting in oct of 2011 that it til now.. You see I only have 2 shot compare to everybody have had it for a year or years... When will my period get here so I can started trying.. My obgyno told me even thou I don't get my period doesn't mean I am not ovulating.. I should try I might be ovulating without a period ... I am skeptical ... My husband did come home Jan 15 to Jan 22 2012 we did try but I don't know if I am preg or not? Havent take a test yet... help !!!

    ReplyDelete
  83. Hello Jan 25th,

    Depo provera effects don't usually last for one year. It should be gone by 3 to 4 months. If it has been 9 months then there is something else going on and you need to be evaluated. I would NOT recommend just going back on Depo provera. You need to find out why your ovaries have not yet started functioning. There is probably a baseline ovarian problem.

    In terms of the IUD, there is a theoretical risk of pelvic infection and more common risk of abnormal bleeding. Also your periods can increase in amount of bleeding, duration and cramping. I do not recommend the IUD for someone who has not had children in the past but it is a good, non-invasive and easy method for those that have had children before.

    In terms of hormones, your question regarding this is a very broad question, but I think the broad answer is that hormones, if used properly and given properly, do more good than harm.

    ReplyDelete
  84. Hello Dash,

    Your doctor is following the proper procedure for trying to get your cycles back to normal. However, in addition, to starting the BCP, she should do a hormone test to see if she can tell what is wrong, as well as, another pregnancy test just to be sure. It is unlikely that the Depo provera is still having an effect on your system. Instead, there might be an ovarian dysfunction. This needs to be corrected becasue one of the long term side effects of an ovarian dysfunction is a hormonal imbalance with an elevation of the male hormone testosterone. This will lead to incrased acne, weight gain, facial hair, diabetes, heart disease.

    If you are battling acne now, the type of birth control pill you use is very important. There are some pills that increase androgen effect, causing more acne, and some that don't. It depends on the progesterone component. In my patients with acne or PCOS, my preference is an OCP called Yaz or Yasmin because the progesterone component will block the testosterone effect at the hair follicle.

    ReplyDelete
  85. Hello Jan 29th,

    I think you should read the response to "Dash" above which has some of the same elements. The Depo should be out of your system now so something else is causing your ovaries to not work. In terms of getting pregnant, yes, it is possible to become pregnant on the first cycle that your ovary ovulates after the Depo and you would not get a period (because you are pregnant). But, this will not occur cycle after cycle. Once the ovaries start functioning again, they should function normally and lead to regular cycles if there are no other ovarian problems.

    Good Luck

    ReplyDelete
  86. Hi I'm currently on the Depo Provera shot I'm due for my next shot in March but im not going to take it because we have decided to try for another baby but i want to speed up the process...i have been diagnosed with endometriosis and have had two laproscopy's last one in Nov2010 cyst were removed and as much of the lesions...ive been taking prenatal vitamins since january, my question is do you think me wanting to start on Provera and then Clomid will help my chances of becoming pregnant

    ReplyDelete
  87. Hello February 14th,

    Clomid, which causes an increase in the number of eggs ovulated per cycle/month, can certainly increase your chances of pregnancy above your natural chances. However, there are many factors involved so the question cannot be answered for sure.

    Good Luck

    ReplyDelete
  88. I was on depo for about 2 years and only missed the shot once before going on depo I was VERY regular like almost to the hour and the one time I missed depo I had a period within 2 weeks went right back in it and my last shot was due dec. 12 2011 and I have not gotten a period but I have had all the symptoms of a period and all symptoms of pregnancy but pregnancy test has came up negative and I have also had almost constant vaginal discharge since depo was due

    ReplyDelete
  89. Hello Feb 25th,

    Is the discharge a brownish color? If it is, this could be a sign of breakthrough bleeding due to an inadequately formed endometrial lining or thinned endometrial lining. My recommendations would be to see your gynecologist who can give you a quick birth control cycle (3 tabs three times per day for 7 days) to get your cycles going. Hopefully, your ovaries will then kick back in and work correctly. If it does not, then you will need an evaluation to find out why the ovaries are not working properly.

    Good Luck.

    ReplyDelete
  90. I had been taking the depo provera shot for 2 - 2 1/2 years and my last shot was due November 4, 2011. I did not get it due the increased risk of bone thinning/loss after 2 years of use. Exactly one week after my shot was due I had a period. It lasted for about 3-5 days. I started bleeding a week later and bled for 14-16 days straight. I saw my doctor about 5-7 days later and she put me on BCP ortho tri cyclen. I started having problems tolerating the BCP by the end of the cycle, so my doctor put me on ortho tri cyclen lo. By this time my husband and I decided that we wanted to have a baby, so I did not take the ortho tri cyclen lo. Since the last time I bled, I have not had any bleeding. I have been having symptoms of pregnancy but have been getting negative pregnancy tests. Could I be pregnant or could I have a ovary dysfunction? Please help!

    ReplyDelete
  91. Hello March 8 Anonymous,

    Before you can conclude that you are not pregnant, you need to have a blood pregnancy test done because it is the most accurate. If it is negative, then you have some type of ovarian dysfunction going on. The treatment would be to induce a period by giving you Provera or an equivalent for five consecutive days and that should bring on a period. If the next cycle does not occur on its own, then an evaluation should be done to find out why. If you desire pregnacy then you may need to use a fertility medication to get the ovary to ovulate.

    ReplyDelete
  92. Hi i only took the depo shot once and plan on not to continue with it. When should i expect my 1st period?

    ReplyDelete
  93. According to the company that makes it, it can take up to six months for all the medication to be removed from your body and the cycles to resume. This is variable, however, so it can be sooner than that as well.

    ReplyDelete
  94. I'm 19 years old, I first started taking depo at age 16. Everything was fine until I had a panic attack but it never cross my my that it was from depo shot. About 18 months after being off depo I got pregnant then back on the shot after I gave birth. I only got one injection never went back for a second shot. Around the time I had severe depression when I started again my doctor knew! I had another panic attack and now I have terrible anxiety. Six months after depo I started spotting for a month on and off. Is my body going back to normal?

    ReplyDelete
  95. Hi, i took the Depo shot for nine months in 2006 when i was a teen and i was experiencing frequent breeding during the shot.Ileft using this method and one year later i started using emergency contraceptives as a birth controlling method for now five years.My periods come every month but days differ from 21 T0 30 days since i was a teen.is that wat we call irregular periods?Sadly i got married last month and i have not conceived no matter the unprotected sex for a full month.Would this pills affected my fertility?please advise me what to do because am worried that i may not conceive at all.

    ReplyDelete
  96. Hello April 8th,

    Sometimes it can take several months for the Depo provera medication to clear your system. It will get back to normal if normal is regular and predictable menstrual cycles. If you had ovarian problems prior to the Depo, you will return to that state.

    Good Luck

    ReplyDelete
  97. Hello April 16th,

    Yes, you have irregular menstrual cyces, which may be due to the day after pills. Keep in mind that whenever you use OCP's as a day afer birth control method, it will "screw up" your cycles because there is a rapid injection of hormone into your system.

    Off the pill, if you are still haveing irregular cycles, then that means that there is an ovarian dysfunction. This will impair your ability to become pregnant, although you might still get lucky. If you want to get pregnant sooner than later, I would recommend that you see an infertility specialist that will treat you with fertility medication to correct the ovulation problem. That may be all that you need.

    Good Luck

    ReplyDelete
  98. im 20 and when i was 15 i got the implanon(bar in my arm) they put it to deep in my arm and needed to be cut open and took ages to get it out when i was 16 as it did not agree with me my periods were very heavy and irregular so i was put on the pill aswell as the bar, after that i got the patch for 2 months then went on the pill for 2 months, when i was 17 i got the injection and since day 1 i have not got a period i came off the injection about 2 months ago as im planning for a baby i was put on the pill until i want to start trying for one but stil have not got my period, at the moment i have suvere pains in the lower part of my tummy where my hips are and its a constant pain that gets worse at some stages i would get really bad cramps this has been happening for about 2 weeks.. please can you give me advice. im wondering now if i even can have children.

    ReplyDelete
  99. I took depo March 11 and never took it again and today is April 12 and still no period. Ive taken progesterone for several months and I bleed after, but when I stop I dont bleed. I took birth control pills for 1 month and have a period, but when I stopped, still no period. Ive taken depo several times and usually my periods will start back within 3months. I want to know is there something wrong and is there anything that can be done to get a normal flow, because iam ttc!

    ReplyDelete
  100. Hi. I need an answer. I wason depo off and on for almost two years. Every three months(a week before my scheduled shot) my cycle would come for a week or more. My scheduled shot was april 24th but I didnt go. I never received my cycle. I have a few pregnancy syptoms, took a test two days ago and it was negative. Starting yesterday ive had an increase in discharge. Its thin, milky, white and odorless. My chest has sharp pains but feels normal to touch. My concern is this pain I have in my lower abdomen and around my navel. Is this the shot?? I need an answer. I can barely sleep....

    ReplyDelete
  101. Hi my name is Paige, well I had twins in 2009 but they passed away because I had them to early. So I decided to get on depo in 2010 of October, so now that I'm getting byolder I decide not to go to my last month depo appointment (april 2012) and due to my bones hurting in my leg and arm and also gaining a lot of weigh. And now I see I want kids of my own in the future. How long would I have to wait to get pregnant ? And is it possible to get pregnant with one child , I don't won't to experience the twin thing again.

    ReplyDelete
  102. Hi I had been on the depo shot since 2002 on and off i stopped it for about 5 years then restarted it in 2009 having 5 injections three months apart, my last one being December 2011, I have just had a blood test to check my fertility and it has come back at 5 the average for my age (36) should be 15, my doctor was very concerned.( until she remembered I was getting the shot ) She then told me the hormone level would come back low due to the depo dtill being in my system, is this right? she has said to wait till dec this year and have my fertility re tested and it should go up. any advice will be greatly appreciated, thanks

    ReplyDelete
  103. Hello April 22nd,

    I cannot tell you what the cause of your pelvic pain is without further testing. There are many problems, and some can affect fertility. In addition, you seem to have an ovulation problem and thus don't have periods regularly. This could be due to hormonal or ovarian issues. I would recommend that you go see a competent specialist in infertility for an evaluation of both problems.

    ReplyDelete
  104. Hello April 27th,

    You have some type of ovulation dysfunction. There are several possiblities, but in order to know the specific problem and treatment, an evaluation needs to be done. This will include hormonal testing to check the hypothalamus, thyroid and pituitary. If these are normal, then the problem is in the ovaries. The treatment to get pregnant would then be the use of fertility medications. This process is called ovulation induction. Make sure you go see a competent specialist in infertility!

    ReplyDelete
  105. Hello May 7th,

    I cannot give you a diagnosis through this venue nor can tell you what might be going on. It is not a Depo provera side effect. I recommend that you go see your doctor and undergo evaluation if you have not already done so.

    ReplyDelete
  106. Hello Paige,

    Once you start having regular cycles again, you can start trying for pregnancy. There is no set amount of time after stopping the Depo provera that you need to wait. Usually it just depends on how long it take for your ovaries to go back to normal function.

    In terms of getting twins again, the chances are higher for you to have a singleton than twins again, so I don't think you need to worry about that.

    ReplyDelete
  107. Hello May 9th,

    There is not such test as a single "fertility test". I'm not sure what number she is referring to. An evaluation for infertility (or fertility) has 9 tests that are done. One of those tests is to check your ovarian function and looks at 5 hormones. There is also a test to see whether or not you are ovulating, which looks at progesterone levels. All these tests need to be done within a normal menstrual cycle. The hormone tests need to be done on the 2nd or 3rd day of the period and the progesterone test is done on cycle day #20,21 or 22 of the cycle.

    Your doctor does not know what she is doing and I would recommend that you find one that does!

    ReplyDelete
    Replies
    1. Thans for the reply Dr Ramirez, I only had the AHM test done. I had my last shot of depo provera in december last year. I am currently on the pill having to take 63 hormone tablets in a row, then stopping for a week, then re starting the pill again I am on a higher Eostrogen pill at the moment as I had a bad bleeding problem due to very thin lining caused my the depo injection and possibly taking primolut tablets, this doctor actually stopped my bleeding by putting me on the pill. She is a IVF Australia doctor, as I am on the pill and still have the provera in my system she said there is no point in doing other hormone tests at the moment. I need to stay on the pill till end of the year to get my cervix lining thicker. It is a long complicated story. But my reading from the AHM test was 5 she said for the average 36 year old it is 15. She has told me that it is possibly the provera still in my system that has made the amh test come back lower than average, so i am going to get it again in december when the provera has hopefully left my system and hopefully it goes up. I was just wondering if from what I have told you above if you think the provera still in my system would cause the amh test to be that much lower than average for my age? Thanks

      Delete
  108. The AMH is not affected by Depo provera or birth control pills, which is one of the benefits of using it (as opposed to FSH). It is a measure of "ovarian reserve" NOT fertility. The level you have is fine. I am also not sure what your doctor is doing with the estrogen and protocol, but you will have to trust her judgement.

    Good Luck

    ReplyDelete
    Replies
    1. Hello Dr. Ramirez,

      I took my first dose of depo on sept. 2010, and then another one on dec. 2010. I decided not too take any more doses due to the fact that my period was coming down for three full months non stop. I missed my third dose in march and decided to get on BCP to regulate my periods. I took the pills intil July and decided with my partner that it was time to try to conceive. Its been a whole year and couple months since Depo could have worn off and I still have'nt gotten pregnant. Could this be due to Depo, and BCP? My periods are normal ever since last year in June, and i do ovulate because I use OPK's. What could be wrong. My yearly appointmaent is in July therefore I would have to wait to find some answers.

      Sincerly Dayana,

      Delete
  109. Hi Dr. Ramirez,
    I had Depo shot on December 2011 an lasted on March 2012. Since then I had a regular period until March. My husband came on April, we had unprotected sex but he pulls out. My period have not arrived until this May. I am experiencing breast tenderness and cramping on my lower abdomen. Ive did a HPT and its negative. Does it correlate the symptoms that I'm pregnant or after effect of hormonal shots? Thank you.
    -denise

    ReplyDelete
  110. Hello Dr Ramirez,

    I hope you can help me. I am 30 years old, and started the Depo injection last year. I only went for it for 3 months...my last one was suppose to be in December 2011 but I never had it. I think the reason for the being the fact that I do want another baby. But now I still have not had my period, that means I am not ovulating. Is this normal? How long will it be before I am ovulating again.

    thank you so much

    Charlene

    ReplyDelete
  111. Hello May 15th,

    Since the withdrawal method is not an optimal contraceptive method, there is the possibility to be pregnant. You can easily answer that question by have a blood pregnancy test. Also, the symptoms could be either residual from the Depo provera, or some other ovarian dysfuntion. You'll have to wait and see how your next cycles are. If they continue to be irregular, then you might want to undergo an evaluation of your hormones.

    Good Luck.

    ReplyDelete
  112. Hello Xcharmonx,

    The company that makes Depo provera states that it can take 6-12 months for normal ovarian function to occur after stopping Depo provera. However, I will usually give it 6 months and if it dose not occur, will assume that there is another ovarian dysfunction going on. This can be checked by a hormonal evaluation. If you did not have regular cycles prior to taking the Depo provera, your ovaries will go back to what they were before and you will have irregular cycles again. If you had regular cycles, it should return to normal unless something else has changed in the interim.

    Good Luck

    ReplyDelete
  113. I took the Depo shot for 3 (+/-) years. My last shot was April 2011, and I did not get my follow up shot in July 2011 because of negative side affects (fatique, consistent weight gain, moodiness, etc.) It has now been almost 14 months since my last shot. I have had one day of spotting (in February) since the last shot. I was told by my gyno that it could take a year.

    Sunday my boyfriend & I had an accident with a condom. I took the Plan B pack (2 pills in 24 hours). Today (Wedensday) I woke up to see a light amount of blood, followed by a brownish discharge for the remainder of the day. My question is, was this a period? If so, when should I see my next one?

    Thank you!

    ReplyDelete
    Replies
    1. Hello May 30th,

      The blood you saw now was from the birth control pill stimulation and withdrawal (Plan B) effects on the endometrial lining. It was not a real period per se meaning a real period implies that there was ovarian function and ovulation. The birth control pill over-rides the ovaries and affects the uterine lining directly.

      It is NOT normal for you not to have a period so long after stopping the Depo provera. You need to have that checked and should start with a hormone panel. The treatment from that point will then depend on the results and how you want to proceed from here.

      Delete
  114. Hello,
    I Have been off of depo for about a half of a month. I only had one shot and still no period the weird thing is i ovulated the day i came off of depo with white clear mucus and i have been crampy ever since but no period. I am trying to conceive so i am not taking any other birth control. I am wondering how would i know if i am ovulating and what can i do about making myself fertile in the meantime. I have asked for clomid but my docter will not prescribe me it because i just came off of the shot. any tips? Also off the depo shot topic i was wondering if you can give me any medical advice i know it would not much since it is over the computer. I have been having pains like pulsating pains in my lower left side of my abdomen for about 3 years now on and off but for the past four days it has come back. I went to my doctor and she had given me and exam and when she toughed my lower left side it was very tender to the touch and she ordered an ultra sound. i am awaiting my appointment but i asked her if it was possibly my ovary and she said its my ovary and my intestin so she could not tell. I have a cyst on that side in my ovary i was told back two years ago and never had it removed. When i stretch my body its hurts there and i can not fully stretch. I guess i am asking what is your intake from this. The next thing i have to ask is about two years ago i had a pap smear done and i came up abnormal because of cells, cancerous. I was pregnant at the time so they said the couldnt do anything untill after i have the baby they would do another pap smear. I just had one done and i have to wait about four weeks for the results so i have no clue what my last pap smear ment but it freaks me out because cancers run in my family and my gramma just had uterin cancer. They did tell me back when i had it done that the cells were still at bay so not to worry. I do know that i do not have any stds or anything like that because i have always came up clean even recently. I hope to hear from you soon and i think its great that you are on here answering people questions. thank you

    ReplyDelete
    Replies
    1. Hello,

      First, when you say you just came off Depo, I presume you mean it has been three months since the last shot, correct? It can take 1-12 months to resume ovulation after depo although most people will cycle normally within 3 months of when the next shot was due. If the Depo is still on board, you will not ovulate, despite what your cervical mucous might indicate. The only way to get the cycle moving along is to do ovulation induction. This can be done with Clomid or Femara, but usually will require stronger medications, like Gonal-f or Follistim to over-ride the Depo. The best thing is just to wait until your cycles resume again.

      In terms of the pain, an ultrasound would be the first step, and then a laparoscopy might be required to look inside.

      In terms of the pap smear, we cannot determine what is present and what to do until the pap smear result returns. You'll just have to wait for that.

      Good Luck

      Delete
  115. Hi there,
    Im so glad i have found this site, really hope you can help.
    I was on depo for six years following the bith of my daughter. I had my last shot in oct 2011 (wearing off jan) but i havent had any period since.
    I seen my gyn who has commenced me on norethisterone 5mg twice daily for ten days then after i have a bleed five days of clomid.
    I have nearly finished my ten day course, was just wondering when i should expect a bleed after taking the last pill and what should i do if i dont get a bleed?

    Also, how effective is this method?

    Thank you very much for your help.

    ReplyDelete
    Replies
    1. Hello June 24th,

      I presume that you are trying again for a pregnancy and that is why Clomid is being given?

      Norethindrone is not a good choice, and obviously your Gyn doctor is basing her treatment on a rote protocol rather than understanding what is going one. However, if your ovaries have had some functioning and you have produce some of an endometrial lining, you should have a bleed.

      If you don't have a bleed then that means that your endometrium did not produce a lining, which is what I would expect if there is still residual effect from the Depo provera (progesterone). In that case, you will need to build the lining and induce a shedding by using the birth control pills for 7 days (1 pill three times per day for 7 days). You will then be ready to undergo ovulation induction to kick start your ovaries (this assumes there is no other problems preventing ovarian function).

      Good Luck

      Delete
  116. Hello, I am 18 years old and got on Depo only one shot(my first time) in February and so it ended at the time of April, haven't had period since then at all though have not gained but instead lost 10 pounds that i couldn't afford to lose since i was only 95 pounds before the lose of weight. i did start to throw out for a period of time after i tried to eat, I'm a little better now but still concerned due to the fact that i have taken pregnancy tests. im not an expert with home pregnancy tests at all, the first two seemed negative though after a couple hours i checked again and they were positive. took 3 more and the rest were negative, but deep within i just don't trust them for some reason. its been about 2 months actual days are 58 since the last day of my last period. i cant eat as much as i use to, but i am eating a bit better compared to how i couldn't eat anything because of the continuous gagging. what does this mean? am i pregnant, am i not? is the shot really messing with my system that much? because i have no answers for myself whatsoever and i have had signs of pregnancy even though it could be the shot by itself. please reply cause I'm really confused. thank you

    ReplyDelete
    Replies
    1. Hello June 29,

      Certainly pregnancy is a possibility and the only way to be sure is to have a blood pregnancy test. You'll need to go to your doctor for a laboratory request. Urine pregnancy tests are made to be done first thing in the morning when the urine is the most concentrated and the highest amount of pregnancy hormone is present, in case you want to test again.

      If the blood pregnancy test is negative, then there is some type of ovarian dysfunction occurring so you will need to see your doctor to follow that up and undergo some additional testing. Treatment will depend on the problems found.

      Good Luck

      Delete
  117. Hello Doctor Edward,
    I had two shot of Depo the next one was due November last year,which I didn't turn up because am trying to get pregnant.I do have periods of which the last two months has been on for the duration of two weeks unlike the prolong one I use to have.Do u think my chances of getting pregnant is great during this time as it has been 9 months since I came off Depo and do have periods two weeks now from my normal period of 5 days.Please reply as your advice will be very helpful.Stephanie.

    ReplyDelete
    Replies
    1. Hello July 7 anonymous,

      If I understand you correctly, you are bleeding for 14 days with the last two periods. This is abnormal and not conducive to getting pregnant. It needs to be evaluated and corrected.

      Good Luck

      Delete
  118. Hi, I'm 17and I have had the shot about twice and its been about 6 months with absolutely no signs of a period or anything. I don't want to continue depo but I would like for periods to return for monthly relief. Is there anyway I can induce?

    ReplyDelete
    Replies
    1. Hello July 8,

      The effects of Depo can last 6-12 months, but there is also the possibility that there is an underlying ovarian dysfunction going on that is preventing you from resuming your periods. This should be evaluated but if your only goal is to have regular cycles again, you can go on a standard birth control pill which will then give you regular periods.

      Delete
  119. i had been on depo since december 2009 to april 2011 and i had one period about 5 months after going off and since then i have not had one what do i need to do to get it back in order i am ready to have another baby after i get married next month and i really need to know please thanks

    ReplyDelete
    Replies
    1. Hello July 12,

      You should have some hormonal testing done to make sure there isn't an underlying hormonal problem that is preventing you from having regular ovulatory cycles. In order to get you regular while you are waiting to have a child, you can use the birth control pill. Hopefully when you get off the pill, things will get back to normal quickly. If you still don't have regular periods and you want to begin trying for pregnancy, and assuming there are no other overwhelming reasons for your ovaries to not work, then you may have to use medications that induce the ovaries to ovulate (called ovulation induction).

      Good Luck

      Delete
  120. Hello!

    My last depo shot was in May of 2011. I deceided that I did not want to get back on because I wanted to have another baby. After months of trying and failing I went to the doctor in April 2012. The doctor said that i should be getting a period and if I dont then to come back and they would get it started. In May I got a period for about 3 days and that was it. I havent had a period since and I really didnt want to take another trip to the doctor. I also tried to find a ovualtion schedule that fit me but I still havent gotten pregnant. Is there something wrong with my body?

    ReplyDelete
    Replies
    1. Hello July 17,

      Yes, there is something wrong with your ovarian function. In order to figure out what is going one, you will have to see a doctor (preferably a specialist in reproductive problems) and undergo evaluation. The problem can be at various levels. Once the problem is identified, then an appropriate treatment can be given.

      As long as your ovaries are not functioning correctly, meaning that they are not ovulating, then you can't get pregnant.

      Good Luck

      Delete
  121. I was in deepo for 1.5yrs,the last shot weared out oct 10th 2011.April 2012 i.e 6 months later i spotted and since i despirately want a baby i went to see a gyna sometimes may.He prescribed primolut n to induce my periods for 2wks of which my periods came and i was to start letrozol on day one of menses for 5days. I did all that and he also prescribed duphaston for ten days to prevent abortion incase i conceive. 8days after taking the duphaston my periods came. Do u think i should go on having fertility drugs on my second cycle of first do a blood test to know what is going on? please advise

    ReplyDelete
    Replies
    1. Hello July 18,

      Your ovaries are not functioning correctly, as I explained to the comment just before yours. In order to get pregnant, your ovaries have to ovulate and that may require using some form of fertility medication. It does not sound to me like you are seeing the proper doctor for your problem, based on how you describe your cycle. I would recommend that you look up "ovulation induction" or "how I do a Clomid cycle" to see how such treatments are properly done.

      I would recommend that you go see a fertility specialist.

      Good Luck

      Delete
  122. Hello doctor, I was on the depo proverb shot from July of 2010 and te last shot I received was on January 3 2012. I was diagnosed in February with carpal tunnel syndrome and I was advised by my doctor to stop the shot because of the chance of bone thinning and it could progress my carpal tunnel. From the time I received my first depo shot I never had another period, and as a teen I always had regular cycles with a moderate flow. Since I have been off of the depo shot I have not had a period, and I have taken home pregnancy tests all turning up negative. I am now newlywed and my husband and I are wanting to start a family, but I am concerned with my lack of menstrual cycle and wondering why my body hasn't returned to normal. All advice is appreciated!

    ReplyDelete
    Replies
    1. Hello July 19,

      It has been too long for the Depo to be affecting your ovarian function so there is something else going on. I would strongly recommend that you go see a fertility specialist to help you find out what the problem is and undergo appropriate treatment so that you can achieve pregnancy sooner than later. Even if you have not been trying long enough to be classified "infertility" it is infertility specialists that treat ovarian dysfunction problems. They are called "reproductive endocrinologists" which a part of being an infertility specialist.

      Good Luck

      Delete
  123. Is there any evidence or research indicating that Depo has any long term effects on hormone production (I.e. resulting from pituitary/ hypothalamic dysfunction)? I had regular to heavy periods as a teen. At 19 my obgyn put me on depo, and I remained on for a little over 2 years. During that time, I gained 70 lbs, terrible acne, depression, terrible miraines, constant bleeding and body hair growth ( to name a few of the side effects--none of which I had prior to depo). Went to the dr every 2-3 months and after 2 years someone finally took me off depo. I have been off of depo for 8 years. It took about 2 years to finally get my newly irregular period. Now it will come every 2 to 6 months - no cysts or endo found. I also still experience bouts of rapid weight gain and acne, which normally settle down after about 6 months. My doctor can't explain it other than to say that the depo is out of my system , so that can't be the cause. However, the it feels very similar to what it was like while I was on the shot. Could the shot have affected my long term hormone function?

    ReplyDelete
    Replies
    1. There is some type of hormonal dysfunction going on in the ovulatory pathway. It is not the Depo provera. You need to undergo evaluation to determine the cause and receive the appropriate treatment. The most common cause is called polycystic ovarian disase (PCOD), but that is not the only possibility. There could also be problems in the hypothalamus, pituitary, thyroid and adrenal, as well as, the ovary. Make sure your doctor checks all of these.

      Delete
  124. I was on Depo for approximately 3 years and went off in 2010. I got a period back immediately and had a 21-22 day cycle. Went on a pill had horrible side effects so stopped it. Had 21-22 day cycles after stopping everything. Used condoms for over a year. Went back on Depo in October 2011 my last shot was in Feb. 2012. I still do not have a period. Tried a month of pills to force a period and nothing. My doctor refuses to do anything for 1 year to 18 months because she thinks that is the normal time to get a period back after Depo. Should I find a new doctor or will they all say it is too soon?

    ReplyDelete
  125. A little more information I had periods every two weeks for 7 days as a teenager and spent years on the pills with horrible side effects before going on the Depo. When I was off birth control they were 21-22 day cycles with periods lasting 3-4 days. I just want my period back as we are ready to start a family.

    ReplyDelete
    Replies
    1. Hi Karen,

      I think you should find another doctor. It is not normal to go this long without a period and if you are wanting to try for pregnancy, it is better to get on the right track. It is likely that there is some type of ovarian dysfunction going on and that will make it difficult to get pregnant, so you might need some infertility treatment to assist.

      Good Luck.

      Delete
  126. Hi Doctor,

    I started the Depo shot in July 2011 and had my last shot at the end of December 2011. I spotted in April 2012 and that's it. I went to the OBGYN today and have to get blood work done and a sonogram to check my hormone levels and to see "what's going on." I was on ortho tri low for 11 years before trying depo but always had a regular "normal" period even when off the pill. Even though the depo is out of my system now, I find it hard to believe it does not have something to do with my lack of menstrual cycle as so many of the woman above have had issues with also. I mean, why now, after all these years and this 3 time use of depo would my ovaries just decide to stop working, I just find it hard to believe depo didn't have a say in this.

    ReplyDelete
  127. Hello doctor,

    I am currently 22. I started the shot in October 2011. My last shot should have been in May 2012. After missing my shot, I menstrated for well over 45 days. I am sexually active and have been using protection. I have taken quite a few pregnancy tests and all negative. I have yet to have another cycle after the initial bleeding. Should I be concerned? What would you recommend to regulate my cycle?

    ReplyDelete
  128. I have been on the shot at two different times. First I was a teen had irregular periods and got on it stayed on it for 1 1/2 years and never seen bleeding for 2 years after. My doctor did some type of scrap of my cervix which cleared it right up started having regular periods. Then in July 06 got pregnant after I went on the pill yaz. Turned around got pregnant July 07 had same due date for both children. After my second we decided no more for awhile so I got back on the shot. Now that we want another child we decided to not do the shot anymore after being on it for 4 years which the last shot was done in May. I don't want to go threw the same thing like I did. Not sure how to bring it up to my doctor without her telling me to wait and see if I get my period on my own which she told me the last time.

    ReplyDelete
  129. Ive been on depo since 2009 my last shot was feb10 of this year...me and my husband are trying to get pregnant as soon as its possible weve been teying for almost 3 weeks now keep in mind i havent had any bleeding or period since starting the shot in 2009 an no sign of one since off.. my questions are ....
    Am i to fresh off the shot to become pregnant?
    What are some things i can do to help get pregnant?
    How long till i should worrie an seek help if im not getting either pregnant or a period?
    If i get pregnant will the baby be affected from me being on depo since 2009 and freshly off?

    Thanks, savannah

    ReplyDelete
  130. Hi Dr. Ramirez,

    August 2011 I had a c-section and welcomed my precious baby boy into the world. I bled for 7 weeks which I believe is normal after having a child. I did not breast feed. A few weeks later I had a normal period. In late Oct I started the depo shot. I missed a period in November but, here's the bad part. I literally bled for SIX months, from Dec 2011 to May 2012. I only received two depo shots and my last shot was in April and I finally stopped bleeding in May. June I received no period. July I had 5 days of light light bleeding. Almost like spotting except it lasted as long as a period. It is now late August and I received no period. I am discharging a lot though (clear discharge). I'm really nervous, did the depo permanently damage my period cycle/ovaries? Why am I discharging? Should I go on birth control and is all of this normal? I see my OB in two weeks but I want to know sooner. I'm nervous because I bled for six months and now have no period and I thought Depo was supposed to make your period stop? If so why did I bleed for 6 months? Any help is appreciated. Thank you!! :)

    Ivana

    ReplyDelete
    Replies
    1. Hello,

      Bleeding for more than a few days after a delivery is NOT normal, and your bleeding problem has been going on for way before starting depo provera. That should have been evaluated and treated a long time a go. Shame on your Ob doctor!

      My worry is that there might be some placental tissue retained within the uterine cavity or some part that was not repaired correctly. Your Gyn doctor needs to evaluate this NOT just put you on some hormonal medication. I would recommend an ultrasound and possibly a hysteroscopy (to look inside). Only then would I recommend trying to treat with hormones. I don't think this is a Depo provera problem.

      Good Luck,

      Dr. Edward J. Ramirez, M.D., FACOG
      Executive Medical Director
      The Fertility and Gynecology Center
      Monterey Bay IVF Program
      www.montereybayivf.com

      Monterey, California, U.S.A.

      for additional information check out my blog at check me out on twitter with me at @montereybayivf and facebook @montereybayivf. Skype and internet comprehensive consultations now available via my website for those who want a more extensive evaluation that this site can accommodate.

      Delete
  131. Hello Doctor. I received only two depo shots and my last was this April. I was a few days late getting my second shot, but they gave me a pregnancy test and it was negative. I haven't had a depo shot since April, but still no periods. I have remained the same weight and felt perfectly normal for months, but I continue to worry that something is wrong. I also have a protein C deficiency.

    ReplyDelete
  132. I have been on the Depo for 12 years due to endometriosis symptoms, yet a recent trip to a new Doctor scared me a bit. She told me I should come off it immediately because iris not recommended to be on it for more than a couple of years maximum. When I asked why, she said "i don't want to frighten you, so I just recommend you come off it ASAP". So, I wanted to ask - why is it not recommended, and also, are there any other options for me that are similar to the Depo? I can't take the pill due to migraines and I'd prefer to not have periods if possible!

    ReplyDelete
    Replies
    1. Your doctor is mistaken. Over a very long term, like 6-8 years, you could develop problems from a lack of estrogen, such as osteoporosis, but short term should not be a problem. I use depo provera for endometriosis in my patients because it helps to block the estrogen affects on endometriosis. My recommendation would be to continue the treatment and find a new gynecologist.

      Good Luck

      Delete
  133. Hi there. My senior year I started the depo shot. I Had the shot two times and was supposed to get it again December of 2011. I went in and decided Not to get the 3rd shot. Although I was due for it. Nor did I get on any other birth control of any type. I decided I wanted my body to get back on track and regulate itself before I started adding another drug. It has been 10 months!!! I have not received a period since then, and I have been having unprotected sex for the last 10 months as well. I'm not pregnant. I've taken home pregnancy test and gone to a doctor for pregnancy test. I don't understand what is going on. I do have spotting and slight bleeding but it's irregular and doesn't last long enough to be a period. Before this I had a regular period. Perfectly healthy that I could pin point the day of, after having the shot only 2x is this normal? What should I do? Please help. It's been 10 months. Sincerely, I wanna be normal again.

    ReplyDelete
    Replies
    1. Hello Daniel,

      It is possible that the Depo is still in your system and causing the problem, but there could also be another problem going on. I would recommend that your hormones be checked to see if there are any other reasons why your ovaries are not back to normal. I presume that you had regular periods before the depo because if your cycle were irregular before, they will return to that state. You may also want to think about cycling for three months with the birth control just to get your ovaries back on track. Sometimes that will help.

      Good Luck

      Delete
  134. Good night,

    I started on depo-provera 6 weeks after I had my son(7/1996) and hasn't had a cycle since September 1996. I got my last shot September 2010 and decided to have the Mirena inserted in February 2011. I hadn't seen my signal in between the time of no birth control so we were hoping the Mirena would have triggered it since most females bleed for up to 3 months after insertion. As of today 09/17/2012, I still haven't seen a cycle I'm a but worried that I won't be able to conceive. Is it possible for Provera to jump start my normal cycles and be as effective with me as it is in most women and also can Clomid be effective in me to jump start a normal ovulation pattern?

    ReplyDelete
  135. Hello-
    I was put on depo after giving birth to my son in 2003. I quit taking it 2 years ago this October. I have not gotten a period at all. Not even a spot. My doctor put me on birth control pills for 2 months. I quit those because I don't want to be on any birth control. She also gave me a couple rounds of provera. Didn't work. I have also taken several rounds of clomid. The clomid was followed up with ultrasounds which showed it was not working either. Only a few follicles that didn't grow over a few days between ultrasounds. I also take 2000 mg of metformin a day. I had a completely normal cycle before depo. My husband and I want a baby :( What do you think?

    ReplyDelete
  136. Hello, I should've got my depo shot in February of this year (2012) it is now September and I've not had my period. Is this normal? Also I'm a big girl, could this affect my wants to get pregnant.

    ReplyDelete
  137. Hiya, my next Depo injection is due on November 16th but I've decided to stop because I've heard it can take a long time to conceive afterwards and I'm desperate to start a family. However, I'm extremely nervous about when my periods will start again and how heavy they could be (as I've also heard they can begin quite irregular). Therefore, I was wondering are there any medications that I could take to make my periods lighter but not affect my chances of getting pregnant?

    ReplyDelete
    Replies
    1. Hi,

      The part about heavier periods after Depo provera is not true. Yes, you could initially have irregular cycles, but in most cases, the cycles and flow will return to the way it was before. What you read about in terms of heavier flow or irregular cycles is because those people probably had that prior before going on Depo provera.

      There is no medication that I can think of to reduce your flow and not affect your fertility. Progesterone is used to reduce flow but it is started early in order to reduce the endometrial lining, which in turn means less tissue to slough and less flow. Doing that reduces fertility because you need a properly thickened endometrial lining for implantation to take place. Progesterone given in the luteal phase as a supplement does not affect the lining thickness because the lining is already adequately thickened before the progesterone is added.

      Good Luck

      Delete
    2. That's set my mind at rest and lifted a lot of stress off my shoulders. Thank you very much.

      Delete
  138. Hi,

    I am 38 years old. I was on depo for 7 years and just stopped it in March of 2012. It is now 7 months later and I still have not had a period, not even spotting. Two months ago, I had horrible pelvic and lower back pain. Felt like ovulation pains x's 100. This month, I had the same pain, around the same day of the month. I have been to the OBGYN, and they found I have a small cyst on each ovary. My original Dr. wanted me to go back on Depo to rid the cysts and stay on it until menopause! I quickly found a new Dr.! My new Dr. thinks my body is trying to work again, and would like to give it a few more months to see if my period comes on it's own. If not, he suggested a jump start with birth control pills. Right now, he is keeping an eye on the cysts. I know that coming off of the depo is what caused the cysts. My ovaries hadn't been operating for 7 years - and now they don't remember what to do. My hormone level's via bloodtest were low, but I am not in premenapause. My Dr. feels the level's will raise. I just don't know how much longer I can go on feeling like this. Tired, anxiety, loss of concentration, and not a great memory. I feel fogged! Is there any hope of regaining my menstral cycle! Depoprovera is a horrible drug!

    ReplyDelete
    Replies
    1. Here's my advice and it may conflict a little with the explanations you have been giving. I hope it helps to clear things up a bit,however.

      You ovaries don't "have to remember" how to function. That is an inherent mechanism. The ovaries does not have a brain and therefore, no memory. It is not working because somehow the mechanism or process within the ovary is not working correctly. It is possible that there is still some Depo left within your system because the company says that lack of periods can last up to 12 months. Hopefully, it will get back on its own.

      Decreased FSH and LH levels are not "perimenopause." In fact, menopause is diagnosed when the levels are increased. That is the FSH and LH are not being taken up by the ovaries so the level in the blood is high. If the levels are low, that means that the hypothalamus-pituitary process is not working or being inhibited. This could be from the Depo since that is how it works.

      Using the birth control pill is a good idea to get your uterus to have monthely cycles, but does nothing for the ovaries. Birth control pills put the ovaries at rest i.e. block the Hypothalamus-Pituitary regulatory cycle, so that ovulation does not occur. It causes periods by working directly on the endometrial (uterine) lining. It is an artificially induced period.

      Delete
  139. Hi Doctor,

    I started my cycle when I was 9yrs old and had severe complications with it. When I was 14, I was finally diagnosed with Endometriosis and was put on Lupron shots to control my pain and bleeding (i would bleed 22 days straight, then nothing for a month or two.) When the Lupron shot made things worse, I was sswitched to Depo Provera at 16 and been on it on and off for the last 4yrs. I recieved my last shot 6months ago due to insurance problems, but I havent had a cycle since then. This hasnt happened to me the previous times ive been on it. I am sexually active with my fiancee and have had several negative pregnancy tests, but the symptoms im currently experiencing is that of a pregnancy. Im not entirely sure whats going on and the Hospital visits dont help much either. Is thete anything you can tell me that will put me at ease?

    ReplyDelete
    Replies
    1. Depo provera can last up to 12 months so the lack of period with a negative pregnancy test (assuming these were blood pregnancy tests) could be explained by persistent Depo provera effects. I cannot explain the pregnancy symptoms, however, but if you are not using any contraception, keep in mind that you would be susceptible to becoming pregnant.

      Delete
  140. Hi there,
    (I previously wrote to you on 24th of june)
    I was on the depo injection for seven years, my last injection ran out Jan 2011.
    I have had numerous blood tests taken, all of which have came back normal (ruled out early menopause and PCOS). However i was not ovulating.
    I was referred to gyn, who commenced me on norithisterone then clomid. Further blood tests showed i did ovulate and went on to have a period.
    That was well over one month ago now and since then i have taken no more pills and my period has unfortunately not returned on its own.
    Im getting married in the summer, and hope to concieve then, but im getting extremely anxious incase there is something wrong with me.
    I am 25 years old, non smoker, no alcohol.
    Health professionals are not interesed and say i need to wait up to two years. The thought of this makes me so upset and feel very low. I also feel misinformed as i was always told it could take up to one year for periods to return.
    I wish someone could help me.
    Sorry for such a long comment, I really really hope you can give me some advice/re-assurance on what to do next.
    Thanks for all of your help once again.

    ReplyDelete
    Replies
    1. Hello,

      First let me say that PCO is not diagnosed by a blood test necessarily. People can have PCOD and still have normal FSH/LH levels. It is diagnosed by meeting at least two of the criteria for PCOD, one of which has to be an ovarian dysfunction (irregular periods or lack of periods).

      So there is the possibility that this is the reason you have irregular or lack of cycles. In that case, if you want to get pregnant, you have to undergo ovulation induction, or using fertility drugs to get the ovaries to function correctly (such as Clomid). You don't need to wait one or two years. If your cycles are irregular, that is enough of a criteria to consider the treatment called ovulation induction.

      Delete
  141. I am 17, my mom and dad put me on the depo shot last year. I took it for exactly a year and stopped it about 4 months ago. I am not sexually active at all. The first month after i stopped i got my period. But havent since then, its been almsot 3 months! is this normal?

    ReplyDelete
    Replies
    1. Hello Ashlynn,

      Yes this can be normal. After Depo provera, sometimes it can take 8-12 months to have your cycles return. In most cases, it is shorter than that but it is very person specific. Not to worry.

      Delete
  142. I was on depo from 10/07/06 My last shot expired on 5/05/11. My periods came back with in a few months and have been pretty regular. I'm ttc and its been almost 18 months since my shot has expired and I'm still not pregnant should I be worried? I'm 25.

    ReplyDelete
    Replies
    1. Since your periods returned, it is an indication that the Depo is no longer in your system. Therefore, your inability to get pregnant is not a result of the Depo provera. Something else must be going on. Since you have been trying for more than one year, I would recommend that you see a fertility specialist and start an infertility evaluation. Only then will the problem or problems be identified and the appropriate treatment given.

      Good Luck

      Delete
    2. Hey just going to let youknow I got pregnant 18 months after stopping depo.

      Delete
  143. hi im 18 years old i was on depo for about 5-6 years well i didn't go back for my last shot because me and my boyfriend wants a baby but, i haven't seen any kind of period yet or any spotting or anything what should we do being that we want a baby soon. being that we are sexual active if he does come inside of me is there a possibly of becoming pregnant.

    ReplyDelete
    Replies
    1. Hello,

      I don't want to sound like your parent, but you do realize that having a baby is a 20 year commitment (financially and emotionally) and that a "boyfriend" is not a permanent relationship so he could just leave when things get tough?

      Pregnancy can occur at any time, and certainly sometimes it occurs after Depo provera is stopped and a regular period hasn't started yet.

      I hope that you will get some pre-pregnancy counseling before you decide to have a child.

      Delete
  144. Hi there,
    I had my first period last month after stopping depo (last injection was Nov 2011), this month im on cycle day 33 and no sign of AF.
    Does it take time for them to regulate once they come back? any advice would be much appreciated.
    Previously wrote to you on 10th oct
    Thank You

    ReplyDelete
    Replies
    1. Hello,

      I'm not sure what you mean by "AF", but once your cycle returns after Depo that is an indication that the Depo provera is no longer in your system. I you don't have regular and predictable cycles, there could be something else going on with your ovaries or hormones. An evaluation would be indicated.

      Good Luck

      Delete
  145. Hi there, thank you for the prompt response.
    (wrote to you on the 12th November)
    Still have no sign of another period despite being on cycle day 40.
    I had an internal ultrasound scan which showed follicles growing on each ovary, it also showed that my endometrial lining is only at 3mm.
    Is this what you would expect after being off the depo for ten months? should the lining start to grow as the injection begins to leave my system?
    thank you so much for you help once again.

    ReplyDelete
    Replies
    1. The endometrial lining will be thin at the beginning of the cycle, and as the estrogen level increases due to a growing ovulatory follicle, the lining will thicken to be adequate for implantation. This will not occur until the ovary returns to normal function.

      Delete
  146. Update from yesterday , period arrived this morning cycle day 40,
    Ultrasound on Saturday showed lining at 3mm, is this normal and should
    The lining start to develop now depo is coming out of my system?
    Thank you again
    Love
    Maria (Scotland)

    ReplyDelete
  147. Hello Dr Edward Ramirez
    I was on Depo Provera for 1 Year and never had a period, My last injection was Febuary what would have covered me until May this year. Me and my long term partner want to try for a baby, That means that ive been off depo provera for almost 7 months and have still not had a period! is this normal? Before going on depo provera i had very regular periods! I was suffering from on and off nausea though out the day, Back aches and sore breasts. I went and had bloods done as i thought i could be pregnant but my blood work came back Negative. I asked my doctor is they could do a Hormone level check, but they said they will not do that until i have been off depo for a whole year. Ive been getting lower stomach cramps asif my period is due, but never turns up. should i go and see a OBGYN?

    Thankyou

    ReplyDelete
    Replies
    1. It is not unheard of for Depo provera to last up to 2 months. So, it may still happen on its own. However, if you are anxious to get pregnant, it would be best for you to go see an Ob/Gyn for further evaluaton.

      Delete
  148. I'm 21 and was only on the Depo shot for 9 months. I went in on time for each shot but continued to have spotting during the time i was on it...so I chose to go off it. A few weeks after i got off it i did have unprotected sex, and still have not had my period, not even spotting. Its been a little over a month since i had sex and I've taken an at home pregnancy test and it was negative.what's going on?

    ReplyDelete
    Replies
    1. Depo provera can linger in your system for a little while. The only way to make sure you are not pregnant is to have a blood pregnancy test done.

      Delete
    2. Yea. I'm not to worried about bring pregnant. I'm more curious about why i would spot while on depo but nothing after

      Delete
    3. Your ovaries have probably not returned to normal function and that is why you aren't having periods. You have the choice of waiting for them to return to normal or kick start them by using the birth control pill for 1-3 cycles. If you are trying for pregnancy, then fertility medication is used instead. It would also be important to do a hormonal evaluation to make sure there is not something else preventing ovarian function, such as thyroid, pituitary or hypothalamus.

      Delete
  149. AMH test results have came back at 3.02pmol/l - very low given my age of 25, however follicles appear healthy, which my dr is saying is unusual.
    I have been told to commence clomid for six months as i previously ovulated on this.
    Is this normal protocol?
    Maria (scotland)

    ReplyDelete
    Replies
    1. I can't comment as to whether or not the use of Clomid is indicated as you don't state what the problem is. Is there a problem? Clomid is not used to treat AMH, which probably is inconsequential at this point.

      In terms of using Clomid, I have written in this blog on how Clomid cycles should be done. I don't recommend just giving a precription for a prescribed period of time and not following the patient. THAT is WRONG.

      Delete
  150. Hi! My gynae said I have endometriosis. This he diagnosed because during his examination I was a bit tender while he was pressing down on my tummy while inserting his fngers inside my vagina. Sorry for the tmi, but I am wondering if tht was enough facts to base such a serious diagnosis on. Also had serious pms and period pain. I even had pms like symptoms for one week after my period ended. Anyway, he put me on depo, the low dose, for 1 month. He says I should get 6 treatments one each month for 6 months. But I have been having some heart palpitations, shortness of breath,wekness, nervousness, dizzines, insomnia. I have gone one treatment already nd I should be getting my next shot this week. But I really think I should stop taking it. What do you think?

    ReplyDelete
    Replies
    1. Hi,

      The diagnosis can only be made by laparoscopy. I would not recommend treatment with Lupron (monthly for 6 months), without that evaluation and diagnosis.

      Delete
  151. I am 21 years old and I got pregnant last year and decided I was not ready for children yet. After my abortion my periods were very normal but I got an IUD for a long term solution but I had a period from the day I got it and horrible cramps so they switched me to the depo. I was due for my second shot and decided I did not like this form of birth control. If i was due for my shot on Nov27-Dec2 when should i expect my periods to return?

    ReplyDelete
  152. I was on depo for 2 years and stopped it last october (2011) now its dec 2012 and ive only had 2 periods one in sept for 3 days and one in nov for about 2 days. I've been to the Dr. and had every test under the sun done (bloodowrk, CT ect). Everything comes back normal. I want to have another child soon and it seems like its not going to happen for me. any advice?

    ReplyDelete
    Replies
    1. There are two options depending on when you want to get pregnant. Basically, the Depo is still in your system and your ovaries need to be re-started. Option one is to use the monthly birth control pill for three months and see if that will induce the ovaries to start up on its own after that or option two is to use fertility medication to induce ovulation, in which case you could try for pregnancy the month you take the medication.

      Delete
  153. Doctor Ramirez,
    I had one depo shot mid October 2011. I did not like the side effects of the shot and decided not to get another one. It has now been 14 months and my period has not returned. I am still nursing my baby who is 15 months old. I nursed my other 3 children this long as well and my period returned no later than 9 months post baby with each of them. I am not in a hurry to have another baby, but I would like to have a regular cycle again just so my husband and I can know what to expect each month as we are using no form of birth control. Would you recommend seeing my doctor to find out what's going on and maybe getting on the pill, or should I wait another few months to a year and see what happens?

    ReplyDelete
    Replies
    1. Hello,

      I didn't need to answer your question because you already had the answer. Why it is taking so long for your ovaries to kick in might be a combination of the Depo effects and breast feeding but regardless, the solution would be the birth control pill as you suggested. There is no reason to wait any longer.

      Good Luck

      Delete
  154. Hi. I am a 32 year old woman that has had painful periods since menstruation began when I was 10. The older I got (between the ages of 18-23) it would take longer and longer to get a period. sometimes 40-50 days. I had ultrasounds done and no cysts were visible. my Doctor say I may have PCOS. I went on DepoProvera from jan of 2004-March of 2006 and it took untill June 2006 to get a period. On october 14th of 2009 I went back on the depo and in July of 2011 I was diagnosed with Type 2 diabetes after taking a steroid called Dekadron (needed a root canal and was Hypoglycemic untill the second day of the steroid) I began taking Metformin (500mg ER 4x daily) and onglyza at bed time. I took my last Depo shot on Aug 23rd 2012. I didn't want to be on the shot anymore because I began to suffer from extreme dryness and itching. I havent been able to have sex in about 8 months due to lack of sex drive, pain, and dryness. My Gyno put me on Oral Provera to start my period now. he didnt want me to wait the 3 months or so to see if it would come back. after taking it for the 5 days and waiting for 2 weeks I still had no period. I went back to the Gyno and saw a Doc different from my own (as he was on vacation at the time) he did a pelvic exam and ordered a blood test for hormones and a pregnancy test. He put me on Lo LoEstrin Fe. 2 pills a day for 7 days. my last pills are tomorrow. I still have no period. I Know the Depo has nothing to do with infertility. But I am scared that I may be in perimenopause or even menopause! While on the Oral Provera and now on the Lo LoEstrin Fe I've had small cramps, a slight return of vaginal moisture, horrible breast tenderness, nausea, and mood swings. I have been in tears for weeks now terrified that I may not be fertile. Scared that I will never have a chance to even try to have children. Is it common for women to go into perimenopause or menopause at 32? Please, if you have any advice I will take it. I feel like my life is over! How long should it be for my period to return after the Lo Loestrin Fe? when should I call my Doctor if it doesnt come back? what other options do I have. I would like to have my body back and to have a baby in the next 4 years. Any hope would be wonderful! Thank you
    Amanda B in Michigan

    ReplyDelete
    Replies
    1. Hi Amanda,

      First, you need to go see a competent doctor that can treat you appropriately. That would be an infertility specialist, not a general Ob/Gyn.

      Second, all the birth control pill does is induce your uterus to menstruate while suppressing the ovaries. The fact that you are on a very very low dose birth control pill could lead to little or no bleeding from the uterus. If you are going to induce a period with birth control pills, you need to use at least a 30 mcg estradiol pill.

      Third, there is such a thig as premature menopause in young women which is a disorder called premature ovarian failure. That diagnosis is made by doing blood hormone tests. If you don't have this disorder, then in order to get pregnant, you would need to undergo an infertility evaluation to make sure there are no other problems, and then go on fertility medications to induce the ovaries to ovulate.

      Delete
  155. Hi Dr.
    i started the depo shot in jan 2009 and got off the depo shot since nov 2011 and began my cycle again in may 2012. my cycles were regular for a couple of months then they began to be irregular. i was wondering whats going on and when will i be able to conceive.

    ReplyDelete
    Replies
    1. Hello,

      You have some type of ovarian dysfunction going on, which means that the ovaries are not working properly. It is not due to the Depo. That is long gone.

      In order to get pregnant, you need to have an evaluation done to find out why your ovaries are not working properly. Then the appropriate treatment can be given to get you to ovulate and therefore get pregnant.

      Good Luck

      Delete
  156. Hi Doctor. Im 30, mother of two and was due for a Depo shot in October after a year of taking it but did not get it due to wanting to come off of it anyway for fear of bone loss. I had very light spotting around Jan 6 th which I discovered on toilet paper. I am now experiencing swollen and tender breast and nipples, nausea, pimples on my face, bloating, a clear mucousy vaginal discharge now and I still have not had a regular period. I've taken three tests and all are negative. I had read past posts and see that it could be several more months before my period returns. However, these other symptoms concern me. Could I be pregnant and it is just too soon to test? My Gyn's practice has moved and I have not found another just yet, please give me your opinion.

    ReplyDelete
  157. Hi. I have only had ONE shot of Depo and expected my cycle to return to normal after a few months. I had one very light bleed but nothing since. I have not had any periods for 14 months now. I have always had light periods prior to this. Recently I was diagnosed with low thyroid funtions and wondered if it may possibly be hormone related for myself. I do generally feel unwell and i am now experiencing very minor cramps. Due to a lower back injury it's difficult to tell what is causing what any more. Thank you for reading.

    ReplyDelete
  158. Hello,

    I had a single shot of Depo in April 2012, and hated it, so I never received the 2nd shot. I had a couple normal periods after, but now they are sporadic and occur like 1-4 days in length, sometimes twice a month, and sometimes I have a sticky, brown discharge when I'm not on my period. I heard that was my uterus lining, but I don't know. Depo has really messed with my cycle. I don't know what to do.

    ReplyDelete

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